HLA-DR-gamma 抗体
(HLA-DR-gamma (CD74))
The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011].
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Latest Publications for our HLA-DR-gamma 抗体
: "Association of variant on the promoter of cluster of differentiation 74 in graves disease and graves ophthalmopathy." in: Bioscience reports, Vol. 40, Issue 8, (2020) (PubMed).: "Examining epitope mutagenesis as a strategy to reduce and eliminate human antibody binding to class II swine leukocyte antigens." in: Immunogenetics, Vol. 71, Issue 7, pp. 479-487, (2019) (PubMed).
: "Synergy between B cell receptor/antigen uptake and MHCII peptide editing relies on HLA-DO tuning." in: Scientific reports, Vol. 9, Issue 1, pp. 13877, (2019) (PubMed).
: "Examining the Biosynthesis and Xenoantigenicity of Class II Swine Leukocyte Antigen Proteins." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 200, Issue 8, pp. 2957-2964, (2018) (PubMed).
: "Expression of macrophage migration inhibitory factor and CD74 in the inner ear and middle ear in lipopolysaccharide-induced otitis media." in: Acta oto-laryngologica, Vol. 136, Issue 10, pp. 1011-6, (2016) (PubMed).
: "Cell Surface CD74-MIF Interactions Drive Melanoma Survival in Response to Interferon-γ." in: The Journal of investigative dermatology, Vol. 135, Issue 11, pp. 2775-84, (2015) (PubMed).
: "A conserved WW domain-like motif regulates invariant chain-dependent cell-surface transport of the NKG2D ligand ULBP2." in: Molecular immunology, Vol. 66, Issue 2, pp. 418-27, (2015) (PubMed).
: "Signal-peptide-peptidase-like 2a is required for CD74 intramembrane proteolysis in human B cells." in: Biochemical and biophysical research communications, Vol. 451, Issue 1, pp. 48-53, (2014) (PubMed).
: "CD74: a new prognostic factor for patients with malignant pleural mesothelioma." in: British journal of cancer, Vol. 110, Issue 8, pp. 2040-6, (2014) (PubMed).
: "The NKG2D ligand ULBP2 is specifically regulated through an invariant chain-dependent endosomal pathway." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 193, Issue 4, pp. 1654-65, (2014) (PubMed).
Aliases for HLA-DR-gamma 抗体
CD74 molecule (CD74) 抗体CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) (Cd74) 抗体
CD74 molecule (Cd74) 抗体
CD74 molecule, major histocompatibility complex, class II invariant chain a (cd74a) 抗体
CD74 molecule, major histocompatibility complex, class II invariant chain b (cd74b) 抗体
cd74 抗体
CLIP 抗体
DHLAG 抗体
HLADG 抗体
Ia-GAMMA 抗体
Iclp-1 抗体
Iclp-2 抗体
iclp1 抗体
iclp2 抗体
II 抗体
Ii 抗体
INVG34 抗体
wu:fb11f09 抗体
wu:fb12a01 抗体
wu:fb13d06 抗体
wu:fk94e07 抗体
zgc:123161 抗体
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