HGF 蛋白
(Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF))
Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
| Catalog no. | 产品 | 适用 | 宿主 / 克隆类型 | 应用 | 价格和交货时间 |
|---|---|---|---|---|---|
| HGF Protein (AA 495-719) (His tag) | 小鼠 | Bacteria |
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| HGF Protein (AA 28-209) (His tag) | 人 | Bacteria |
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| HGF Protein (AA 32-728) | 人 | Mammalian Cells |
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| HGF Protein (DYKDDDDK Tag) | 人 | HEK-293 Cells |
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| HGF 蛋白 | 人 | CHO Cells |
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| HGF Protein (Chain B) | 人 | – |
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| HGF Protein (Chain A) | 人 | – |
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| HGF Protein (His tag) | 人 | 大肠杆菌（E. Coli） |
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| HGF Protein (His tag) | 人 | Mammalian Cells |
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| HGF Protein (His tag) | 小鼠 | 大肠杆菌（E. Coli） |
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| HGF Protein (His tag) | Cow | 大肠杆菌（E. Coli） |
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Protein
- Func (Functional Studies: 所列应用)
- 宿主
- 人
- 宿主
- Mammalian Cells
- 蛋白类型
- Recombinant
- 纯度
- >95 % as determined by SDS-PAGE.
- 生物活性
- Active
Protein
- 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- The purity of the protein is greater than 90 % as determined by SDS-PAGE and Coomassie blue staining.
Protein
- WB (Western Blotting: 所列应用)
- SDS (SDS-PAGE: 所列应用)
- Imm (Immunogen: 所列应用)
- ELISA (ELISA: 所列应用)
- 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
Protein
- WB (Western Blotting: 所列应用)
- SDS (SDS-PAGE: 所列应用)
- Imm (Immunogen: 所列应用)
- ELISA (ELISA: 所列应用)
- 宿主
- 人
- 宿主
- Mammalian Cells
- 蛋白类型
- Recombinant
Protein
- WB (Western Blotting: 所列应用)
- SDS (SDS-PAGE: 所列应用)
- Imm (Immunogen: 所列应用)
- ELISA (ELISA: 所列应用)
- 宿主
- 小鼠
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
Protein
- WB (Western Blotting: 所列应用)
- SDS (SDS-PAGE: 所列应用)
- 宿主
- Cow
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 90 %
Latest Publications for our HGF 蛋白
: "Chidamide increases the sensitivity of Non-small Cell Lung Cancer to Crizotinib by decreasing c-MET mRNA methylation." in: International journal of biological sciences, Vol. 16, Issue 14, pp. 2595-2611, (2020) (PubMed).
: "Blood vessel endothelium-directed tumor cell streaming in breast tumors requires the HGF/C-Met signaling pathway." in: Oncogene, (2016) (PubMed).
: "Therapeutic Potential of Anti-Angiogenic Multitarget N,O-Sulfated E. Coli K5 Polysaccharide in Diabetic Retinopathy." in: Diabetes, Vol. 64, Issue 7, pp. 2581-92, (2015) (PubMed).
: "Endothelial Cells Derived from Non-malignant Tissues Are of Limited Value as Models for Brain Tumor Vasculature." in: Anticancer research, Vol. 35, Issue 5, pp. 2681-90, (2015) (PubMed).
: "PAX2 promoted prostate cancer cell invasion through transcriptional regulation of HGF in an in vitro model." in: Biochimica et biophysica acta, Vol. 1852, Issue 11, pp. 2467-73, (2015) (PubMed).
: "Heat-shock protein 27 (HSP27, HSPB1) is up-regulated by MET kinase inhibitors and confers resistance to MET-targeted therapy." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 28, Issue 9, pp. 4055-67, (2015) (PubMed).
: "Primary structure of rat hepatocyte growth factor and induction of its mRNA during liver regeneration following hepatic injury." in: European journal of biochemistry / FEBS, Vol. 193, Issue 2, pp. 375-81, (1990) (PubMed).
: "Deduced primary structure of rat hepatocyte growth factor and expression of the mRNA in rat tissues." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 8, pp. 3200-4, (1990) (PubMed).
: "Blood vessel endothelium-directed tumor cell streaming in breast tumors requires the HGF/C-Met signaling pathway." in: Oncogene, (2016) (PubMed).
: "Therapeutic Potential of Anti-Angiogenic Multitarget N,O-Sulfated E. Coli K5 Polysaccharide in Diabetic Retinopathy." in: Diabetes, Vol. 64, Issue 7, pp. 2581-92, (2015) (PubMed).
: "Endothelial Cells Derived from Non-malignant Tissues Are of Limited Value as Models for Brain Tumor Vasculature." in: Anticancer research, Vol. 35, Issue 5, pp. 2681-90, (2015) (PubMed).
: "PAX2 promoted prostate cancer cell invasion through transcriptional regulation of HGF in an in vitro model." in: Biochimica et biophysica acta, Vol. 1852, Issue 11, pp. 2467-73, (2015) (PubMed).
: "Heat-shock protein 27 (HSP27, HSPB1) is up-regulated by MET kinase inhibitors and confers resistance to MET-targeted therapy." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 28, Issue 9, pp. 4055-67, (2015) (PubMed).
: "Primary structure of rat hepatocyte growth factor and induction of its mRNA during liver regeneration following hepatic injury." in: European journal of biochemistry / FEBS, Vol. 193, Issue 2, pp. 375-81, (1990) (PubMed).
: "Deduced primary structure of rat hepatocyte growth factor and expression of the mRNA in rat tissues." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 8, pp. 3200-4, (1990) (PubMed).
Aliases for HGF 蛋白
hepatocyte growth factor (HGF) 蛋白hepatocyte growth factor (Hgf) 蛋白
C230052L06Rik 蛋白
DFNB39 蛋白
F-TCF 蛋白
HGF 蛋白
HGF/SF 蛋白
HGFB 蛋白
HPTA 蛋白
NK1 蛋白
NK2 蛋白
SF 蛋白
SF/HGF 蛋白
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