HDAC8 产品
(Histone Deacetylase 8 (HDAC8))
Categories
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
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Featured HDAC8 Categories
HDAC8 抗体
High quality antibodies with extensive validation data.
HDAC8 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
HDAC8 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
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Recommended HDAC8 ELISA试剂盒
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Recommended HDAC8 蛋白
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Latest Publications for our HDAC8 Products
: "HDAC8 Regulates a Stress Response Pathway in Melanoma to Mediate Escape from BRAF Inhibitor Therapy." in: Cancer research, Vol. 79, Issue 11, pp. 2947-2961, (2019) (PubMed).: "Regulation of Retinoic Acid Inducible Gene-I (RIG-I) Activation by the Histone Deacetylase 6." in: EBioMedicine, Vol. 9, pp. 195-206, (2017) (PubMed).
: "HDAC8 and STAT3 repress BMF gene activity in colon cancer cells." in: Cell death & disease, Vol. 5, pp. e1476, (2014) (PubMed).
: "The tricyclic antidepressant amitriptyline inhibits D-cyclin transactivation and induces myeloma cell apoptosis by inhibiting histone deacetylases: in vitro and in silico evidence." in: Molecular pharmacology, Vol. 79, Issue 4, pp. 672-80, (2011) (PubMed).
: "Histone deacetylase inhibitors stimulate histone H3 lysine 4 methylation in part via transcriptional repression of histone H3 lysine 4 demethylases." in: Molecular pharmacology, Vol. 79, Issue 1, pp. 197-206, (2010) (PubMed).
: "Negative regulation of histone deacetylase 8 activity by cyclic AMP-dependent protein kinase A." in: Molecular and cellular biology, Vol. 24, Issue 2, pp. 765-73, (2003) (PubMed).
: "Cloning and characterization of a novel human class I histone deacetylase that functions as a transcription repressor." in: The Journal of biological chemistry, Vol. 275, Issue 20, pp. 15254-64, (2000) (PubMed).
: "Characterization of a highly complex region in Xq13 and mapping of three isodicentric breakpoints associated with preleukemia." in: Genomics, Vol. 64, Issue 3, pp. 221-9, (2000) (PubMed).
: "Cloning and characterization of human histone deacetylase 8." in: FEBS letters, Vol. 478, Issue 1-2, pp. 77-83, (2000) (PubMed).
Synonyms and alternative names related to HDAC8
histone deacetylase 8 (CC1G_05302), histone deacetylase 8 (hdac8), histone deacetylase 8 (HDAC8), histone deacetylase 8 (Hdac8), histone deacetylase 8 L homeolog (hdac8.L), histone deacetylase 8 (HDA08), 2610007D20Rik, ATHDA8, CDLS5, HD8, HDA8, HDACL1, HISTONE DEACETYLASE 8, histone deacetylase 8, MRXS6, RGD1562895, RPD3, T27G7.14, T27G7_14, WTS, wu:fd19a02, zgc:66196Protein level used designations for HDAC8
- histone deacetylase 8
- histone deacetylase-like 1
- HD8
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