GRIA2 产品
(Glutamate Receptor, Ionotropic, AMPA 2 (GRIA2))
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Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG\; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008].
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Featured GRIA2 Categories
GRIA2 抗体
High quality antibodies with extensive validation data.
GRIA2 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
GRIA2 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended GRIA2 抗体
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Reactivity
Application
Validations
Cat. No.
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Datasheet
Reactivity
Human
Application
WB, IHC, IF
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- (6)
Cat. No.
ABIN7267414
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, FACS
Validations
- (2)
- (5)
Cat. No.
ABIN969524
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA, FACS, ICC, Neut
Validations
- (5)
Cat. No.
ABIN5611163
Quantity
0.1 mg
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Recommended GRIA2 ELISA试剂盒
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Analytical Method
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Cat. No.
ABIN6956147
Quantity
96 tests
Datasheet
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Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6956148
Quantity
96 tests
Datasheet
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Reactivity
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Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN1503159
Quantity
96 tests
Datasheet
Datasheet
Recommended GRIA2 蛋白
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Source
Escherichia coli (E. coli)
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- (1)
Cat. No.
ABIN3080937
Quantity
1 mg
Datasheet
Datasheet
Reactivity
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Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN3133383
Quantity
1 mg
Datasheet
Datasheet
Reactivity
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Insect Cells
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Cat. No.
ABIN3092808
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Latest Publications for our GRIA2 Products
: "Modulation of synaptic plasticity, motor unit physiology, and TDP-43 pathology by CHCHD10." in: Acta neuropathologica communications, Vol. 10, Issue 1, pp. 95, (2022) (PubMed).: "Loss of the golgin GM130 causes Golgi disruption, Purkinje neuron loss, and ataxia in mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, Issue 2, pp. 346-351, (2018) (PubMed).
: "Dcf1 Triggers Dendritic Spine Formation and Facilitates Memory Acquisition." in: Molecular neurobiology, Vol. 55, Issue 1, pp. 763-775, (2018) (PubMed).
: "Specific Alterations in Astrocyte Properties via the GluA2-GAPDH Complex Associated with Multiple Sclerosis." in: Scientific reports, Vol. 8, Issue 1, pp. 12856, (2018) (PubMed).
: "The paracrine effect of cobalt chloride on BMSCs during cognitive function rescue in the HIBD rat." in: Behavioural brain research, Vol. 332, pp. 99-109, (2017) (PubMed).
: "Cell-free methods to produce structurally intact mammalian membrane proteins." in: Scientific reports, Vol. 6, pp. 30442, (2016) (PubMed).
: "Dynamics of the mouse brain cortical synaptic proteome during postnatal brain development." in: Scientific reports, Vol. 6, pp. 35456, (2016) (PubMed).
: "Disrupting GluA2-GAPDH Interaction Affects Axon and Dendrite Development." in: Scientific reports, Vol. 6, pp. 30458, (2016) (PubMed).
: "Neuroligin-1 regulates excitatory synaptic transmission, LTP and EPSP-spike coupling in the dentate gyrus in vivo." in: Brain structure & function, Vol. 220, Issue 1, pp. 47-58, (2015) (PubMed).
: "TRPC3 channels critically regulate hippocampal excitability and contextual fear memory." in: Behavioural brain research, Vol. 281, pp. 69-77, (2015) (PubMed).
Synonyms and alternative names related to GRIA2
glutamate ionotropic receptor AMPA type subunit 2 (GRIA2), glutamate receptor, ionotropic, AMPA 2 (GRIA2), glutamate receptor, ionotropic, AMPA2 (alpha 2) (Gria2), glutamate ionotropic receptor AMPA type subunit 2 (Gria2), glutamate receptor, ionotropic, AMPA 2a (gria2a), glutamate receptor, ionotropic, AMPA 2 S homeolog (gria2.S), GluA2, GluR-2, Glur-2, GluR-B, gluR-B, GluR-K2, GLUR2, Glur2, GluR2, glur2, glur2a, GLURB, gria2.1, HBGR2, zfGRIA2[a]Protein level used designations for GRIA2
- AMPA-selective glutamate receptor 2
- gluR-2
- gluR-B
- glutamate receptor 2
- Glutamate receptor 2
- gluR-K2
- glutamate receptor ionotropic, AMPA 2
- AMPA selective glutamate receptor
- glutamate receptor B
- glutamate receptor, ionotropic, AMPA 2.1
- AMPA glutamate receptor 2
- AMPA receptor GluR2/B
- glutamate receptor AMPA 2
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