This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].
Kim, Sung, Youn, Park: "Gremlin-1 activates Akt/STAT3 signaling, which increases the glycolysis rate in breast cancer cells." in: Biochemical and biophysical research communications, Vol. 533, Issue 4, pp. 1378-1384, (2020) (PubMed).
Aliases for GREM1 蛋白
gremlin 1a, DAN family BMP antagonist (grem1a) 蛋白 gremlin 1, DAN family BMP antagonist (GREM1) 蛋白 gremlin 1 (LOC662541) 蛋白 gremlin 1, DAN family BMP antagonist (grem1) 蛋白 gremlin 1, DAN family BMP antagonist (Grem1) 蛋白 gremlin 1, DAN family BMP antagonist L homeolog (grem1.L) 蛋白 Cktsf1b1 蛋白 CKTSF1B1 蛋白 cktsf1b1 蛋白 dand2 蛋白 DAND2 蛋白 drm 蛋白 Drm 蛋白 DRM 蛋白 Grem 蛋白 grem1 蛋白 GREM1 蛋白 gremlin 蛋白 GREMLIN 蛋白 gremlin-1 蛋白 ihg-2 蛋白 IHG-2 蛋白 ld 蛋白 MGC136702 蛋白 pig2 蛋白 zgc:136702 蛋白