This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011].
Lindsey, Jiang, Woulfe, Papoutsakis: "Platelets from mice lacking the aryl hydrocarbon receptor exhibit defective collagen-dependent signaling." in: Journal of thrombosis and haemostasis : JTH, Vol. 12, Issue 3, pp. 383-94, (2014) (PubMed).
Inoue, Suzuki-Inoue, Dean, Frampton, Watson: "Integrin alpha2beta1 mediates outside-in regulation of platelet spreading on collagen through activation of Src kinases and PLCgamma2." in: The Journal of cell biology, Vol. 160, Issue 5, pp. 769-80, (2003) (PubMed).
Jandrot-Perrus, Busfield, Lagrue, Xiong, Debili, Chickering, Le Couedic, Goodearl, Dussault, Fraser, Vainchenker, Villeval: "Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily." in: Blood, Vol. 96, Issue 5, pp. 1798-807, (2000) (PubMed).
Aliases for GP6 抗体
glycoprotein VI platelet (GP6) 抗体 glycoprotein 6 (platelet) (Gp6) 抗体 glycoprotein VI (Gp6) 抗体 glycoprotein VI platelet (Gp6) 抗体 platelet glycoprotein VI (LOC103346235) 抗体 9830166G18Rik 抗体 BDPLT11 抗体 Gm469 抗体 GP6 抗体 GPIV 抗体 GPVI 抗体 Gpvi 抗体