(Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 1 (GGA1))
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
von Arnim, Spoelgen, Peltan, Deng, Courchesne, Koker, Matsui, Kowa, Lichtenthaler, Irizarry, Hyman: "GGA1 acts as a spatial switch altering amyloid precursor protein trafficking and processing." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 26, Issue 39, pp. 9913-22, (2006) (PubMed).
Shiba, Kawasaki, Takatsu, Nogi, Matsugaki, Igarashi, Suzuki, Kato, Nakayama, Wakatsuki: "Molecular mechanism of membrane recruitment of GGA by ARF in lysosomal protein transport." in: Nature structural biology, Vol. 10, Issue 5, pp. 386-93, (2003) (PubMed).
Zhu, Zhai, He, Terzyan, Zhang, Joachimiak, Tang, Zhang: "Crystal structure of the human GGA1 GAT domain." in: Biochemistry, Vol. 42, Issue 21, pp. 6392-9, (2003) (PubMed).
Zhai, He, Liu, Wakeham, Zhu, Li, Tang, Zhang: "The interaction of the human GGA1 GAT domain with rabaptin-5 is mediated by residues on its three-helix bundle." in: Biochemistry, Vol. 42, Issue 47, pp. 13901-8, (2003) (PubMed).