(Golgi Brefeldin A Resistant Guanine Nucleotide Exchange Factor 1 (GBF1))
This gene encodes a member of the Sec7 domain family. The encoded protein is a guanine nucleotide exchange factor that regulates the recruitment of proteins to membranes by mediating GDP to GTP exchange. The encoded protein is localized to the Golgi apparatus and plays a role in vesicular trafficking by activating ADP ribosylation factor 1. The encoded protein has also been identified as an important host factor for viral replication. Multiple transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010].
Claude, Zhao, Kuziemsky, Dahan, Berger, Yan, Armold, Sullivan, Melançon: "GBF1: A novel Golgi-associated BFA-resistant guanine nucleotide exchange factor that displays specificity for ADP-ribosylation factor 5." in: The Journal of cell biology, Vol. 146, Issue 1, pp. 71-84, (1999) (PubMed).
Mansour, Herbrick, Scherer, Melançon: "Human GBF1 is a ubiquitously expressed gene of the sec7 domain family mapping to 10q24." in: Genomics, Vol. 54, Issue 2, pp. 323-7, (1999) (PubMed).