Preferentially catalyzes the dephosphorylation of 'Ser- 5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation (By similarity). Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.
Latest Publications for our Gastric Inhibitory Polypeptide 抗体
Banerjee, Zoetewey, Ovee, Mazumder, Petrenko, Samoylova, Mohanty: "Specificity and promiscuity in human glutaminase interacting protein recognition: insight from the binding of the internal and C-terminal motif." in: Biochemistry, Vol. 51, Issue 35, pp. 6950-60, (2012) (PubMed).