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FUS 产品

(Fused in Sarcoma (FUS))
This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009].

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Featured FUS Categories

FUS 抗体

High quality antibodies with extensive validation data.

FUS ELISA试剂盒

Reliable ELISA kits for a wide range of species.

FUS 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended FUS 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Cow, Dog, Human, Mouse, Pig, Rabbit, Rat
Application WB, IHC
Validations
  • (6)
Cat. No. ABIN2778717
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, ELISA, IHC, IF, FACS
Validations
  • (7)
Cat. No. ABIN3031006
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IF, IP
Validations
  • (4)
Cat. No. ABIN6140818
Quantity 100 μL
Datasheet Datasheet

Recommended FUS ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6966914
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1156242
Quantity 96 tests
Datasheet Datasheet
Reactivity Cow
Analytical Method
Validations
Cat. No. ABIN1156240
Quantity 96 tests
Datasheet Datasheet

Recommended FUS 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7123020
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (5)
  • (1)
Cat. No. ABIN2721461
Quantity 20 μg
Datasheet Datasheet
Reactivity Human respiratory syncytial virus B
Source Yeast
Validations
  • (1)
Cat. No. ABIN5714278
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our FUS Products

Martinez-Macias, Moore, Green, Gomez-Herreros, Naumann, Hermann, Van Damme, Hafezparast, Caldecott: "FUS (fused in sarcoma) is a component of the cellular response to topoisomerase I-induced DNA breakage and transcriptional stress." in: Life science alliance, Vol. 2, Issue 2, (2019) (PubMed).

Singatulina, Hamon, Sukhanova, Desforges, Joshi, Bouhss, Lavrik, Pastré: "PARP-1 Activation Directs FUS to DNA Damage Sites to Form PARG-Reversible Compartments Enriched in Damaged DNA." in: Cell reports, Vol. 27, Issue 6, pp. 1809-1821.e5, (2019) (PubMed).

Mori, Honda, Ishii, Yoshimura, Sasagasako, Suzuki, Taniwaki, Iwaki: "Expanded polyglutamine impairs normal nuclear distribution of fused in sarcoma and poly (rC)-binding protein 1 in Huntington's disease." in: Neuropathology : official journal of the Japanese Society of Neuropathology, Vol. 39, Issue 5, pp. 358-367, (2019) (PubMed).

Gittings, Foti, Benson, Gami-Patel, Isaacs, Lashley: "Heterogeneous nuclear ribonucleoproteins R and Q accumulate in pathological inclusions in FTLD-FUS." in: Acta neuropathologica communications, Vol. 7, Issue 1, pp. 18, (2019) (PubMed).

Li, Song, Moh, Kim, Kim: "Cytoplasmic Restriction of Mutated SOD1 Impairs the DNA Repair Process in Spinal Cord Neurons." in: Cells, Vol. 8, Issue 12, (2019) (PubMed).

Pansarasa, Bordoni, Drufuca, Diamanti, Sproviero, Trotti, Bernuzzi, La Salvia, Gagliardi, Ceroni, Cereda: "Lymphoblastoid cell lines as a model to understand amyotrophic lateral sclerosis disease mechanisms." in: Disease models & mechanisms, Vol. 11, Issue 3, (2018) (PubMed).

Moore, Blachere, Fak, Park, Sawicka, Parveen, Zucker-Scharff, Moltedo, Rudensky, Darnell: "ZFP36 RNA-binding proteins restrain T cell activation and anti-viral immunity." in: eLife, Vol. 7, (2018) (PubMed).

Wang, Grunseich, Fox, Burdick, Zhu, Ravazian, Hafner, Cheung: "Human proteins that interact with RNA/DNA hybrids." in: Genome research, Vol. 28, Issue 9, pp. 1405-1414, (2018) (PubMed).

Bogaert, Boeynaems, Kato, Guo, Caulfield, Steyaert, Scheveneels, Wilmans, Haeck, Hersmus, Schymkowitz, Rousseau, Shorter, Callaerts, Robberecht, Van Damme, Van Den Bosch: "Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity." in: Cell reports, Vol. 24, Issue 3, pp. 529-537.e4, (2018) (PubMed).

Gorthi, Romero, Loranc, Cao, Lawrence, Goodale, Iniguez, Bernard, Masamsetti, Roston, Lawlor, Toretsky, Stegmaier, Lessnick, Chen, Bishop: "EWS-FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma." in: Nature, Vol. 555, Issue 7696, pp. 387-391, (2018) (PubMed).

Synonyms and alternative names related to FUS

FUS RNA binding protein (FUS), fused in sarcoma (Fus), FUS RNA binding protein (Fus), fused in sarcoma (FUS), ALS6, D430004D17Rik, D930039C12Rik, ETM4, FUS/TLS, FUS1, Fus1, HNRNPP2, POMP75, TLS, Tls

Protein level used designations for FUS

  • 75 kDa DNA-pairing protein
  • RNA-binding protein FUS
  • fus-like protein
  • fusion gene in myxoid liposarcoma
  • heterogeneous nuclear ribonucleoprotein P2
  • oncogene FUS
  • oncogene TLS
  • translocated in liposarcoma protein
  • fusion, derived from t(12;16) malignant liposarcoma
  • hnRNP P2
  • pigpen protein
  • protein pigpen
  • translocated in liposarcoma
  • fusion
  • pigpen
  • fusion (involved in t(12;16) in malignant liposarcoma)
  • 16) in malignant liposarcoma)
  • 16) malignant liposarcoma
  • fusion (involved in t(12
  • fusion, derived from t(12
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