This gene encodes a protein with similarity to follistatin, an activin-binding protein. It contains an FS module, a follistatin-like sequence containing 10 conserved cysteine residues. This gene product is thought to be an autoantigen associated with rheumatoid arthritis. [provided by RefSeq, Jul 2008].
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Tanaka, Ozaki, Osakada, Mori, Okubo, Nakao: "Cloning of follistatin-related protein as a novel autoantigen in systemic rheumatic diseases." in: International immunology, Vol. 10, Issue 9, pp. 1305-14, (1998) (PubMed).