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FRS2 产品

(Fibroblast Growth Factor Receptor Substrate 2 (FRS2))

Categories

Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3- kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.

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Featured FRS2 Categories

FRS2 抗体

High quality antibodies with extensive validation data.

FRS2 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

FRS2 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended FRS2 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Application WB, IHC (p)
Validations
  • (1)
  • (3)
Cat. No. ABIN2855603
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, ELISA
Validations
  • (3)
Cat. No. ABIN3184696
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (2)
Cat. No. ABIN7439384
Quantity 100 μL
Datasheet Datasheet

Recommended FRS2 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6966795
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6966796
Quantity 96 tests
Datasheet Datasheet
Reactivity Cow
Analytical Method Quantitative Competition ELISA
Validations
Cat. No. ABIN991779
Quantity 96 tests
Datasheet Datasheet

Recommended FRS2 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (2)
  • (1)
Cat. No. ABIN1354441
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7122957
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1354439
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our FRS2 Products

Bitzer, Spahn, Babaei, Horger, Singer, Schulze-Osthoff, Missios, Gatidis, Nann, Mattern, Scheble, Nikolaou, Armeanu-Ebinger, Schulze, Schroeder, Biskup, Beha, Claassen, Ruhm, Poso, Malek: "Targeting extracellular and juxtamembrane FGFR2 mutations in chemotherapy-refractory cholangiocarcinoma." in: NPJ precision oncology, Vol. 5, Issue 1, pp. 80, (2021) (PubMed).

Sun, Zou, Yang, Morita, Gong, Shiba, Akagawa, Yuan: "Inorganic polyphosphates stimulate FGF23 expression through the FGFR pathway." in: Biochemical and biophysical research communications, Vol. 428, Issue 2, pp. 298-302, (2012) (PubMed).

Krejci, Salazar, Goodridge, Kashiwada, Schibler, Jelinkova, Thompson, Wilcox: "STAT1 and STAT3 do not participate in FGF-mediated growth arrest in chondrocytes." in: Journal of cell science, Vol. 121, Issue Pt 3, pp. 272-81, (2008) (PubMed).

Krejci, Masri, Salazar, Farrington-Rock, Prats, Thompson, Wilcox: "Bisindolylmaleimide I suppresses fibroblast growth factor-mediated activation of Erk MAP kinase in chondrocytes by preventing Shp2 association with the Frs2 and Gab1 adaptor proteins." in: The Journal of biological chemistry, Vol. 282, Issue 5, pp. 2929-36, (2007) (PubMed).

Synonyms and alternative names related to FRS2

fibroblast growth factor receptor substrate 2 (FRS2), fibroblast growth factor receptor substrate 2b (frs2b), fibroblast growth factor receptor substrate 2 (Frs2), 4732458E18, C330018A15Rik, frs2, FRS2A, FRS2alpha, Frs2alpha, SNT, SNT-1, SNT1, wu:fd21h10, zgc:91973

Protein level used designations for FRS2

  • fibroblast growth factor receptor substrate 2
  • FGFR signalling adaptor
  • FGFR substrate 2
  • FGFR-signaling adaptor SNT
  • suc1-associated neurotrophic factor target 1
  • FRS2-alpha
  • SNT-1
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