This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Nov 2008].
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Lee, Pi, Lee: "Buffer optimization for high resolution of human lung cancer tissue proteins by two-dimensional gel electrophoresis." in: Biotechnology letters, Vol. 31, Issue 1, pp. 31-7, (2008) (PubMed).