Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene. [provided by RefSeq, Jul 2008].
Liu, Ukomadu: "Fibrinogen-like protein 1, a hepatocyte derived protein is an acute phase reactant." in: Biochemical and biophysical research communications, Vol. 365, Issue 4, pp. 729-34, (2007) (PubMed).
Rijken, Dirkx, Luider, Leebeek: "Hepatocyte-derived fibrinogen-related protein-1 is associated with the fibrin matrix of a plasma clot." in: Biochemical and biophysical research communications, Vol. 350, Issue 1, pp. 191-4, (2006) (PubMed).