(Fibroblast Growth Factor Binding Protein 1 (FGFBP1))
This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011].
Taetzsch, Tenga, Valdez: "Muscle Fibers Secrete FGFBP1 to Slow Degeneration of Neuromuscular Synapses during Aging and Progression of ALS." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 37, Issue 1, pp. 70-82, (2017) (PubMed).
Asparuhova, Secondini, Rüegg, Chiquet-Ehrismann: "Mechanism of irradiation-induced mammary cancer metastasis: A role for SAP-dependent Mkl1 signaling." in: Molecular oncology, (2015) (PubMed).
Aliases for FGFBP1 抗体
fibroblast growth factor binding protein 1 S homeolog (fgfbp1.S) 抗体 fibroblast growth factor binding protein 1 (FGFBP1) 抗体 fibroblast growth factor binding protein 1 (fgfbp1) 抗体 fibroblast growth factor binding protein 1 (Fgfbp1) 抗体 fibroblast growth factor-binding protein 1 (LOC100726816) 抗体 fibroblast growth factor-binding protein 1 (LOC101106941) 抗体 FGF-BP 抗体 FGF-BP1 抗体 fgfbp 抗体 FGFBP 抗体 FGFBP-1 抗体 hbp17 抗体 HBP17 抗体 MGC84401 抗体