(Fc Fragment of IgG, Low Affinity IIIb, Receptor (CD16b) (FCGR3B))
The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1. [provided by RefSeq, Aug 2012].
Aoyama, Hashii, Tsukimura, Osumi, Harazono, Tada, Kiyoshi, Matsuda, Ishii-Watabe: "Effects of terminal galactose residues in mannose α1-6 arm of Fc-glycan on the effector functions of therapeutic monoclonal antibodies." in: mAbs, Vol. 11, Issue 5, pp. 826-836, (2020) (PubMed).
Simonov, Ivanov, Smolov, Abbasova, Piskunov, Poteryaev: "Control of therapeutic IgG antibodies galactosylation during cultivation process and its impact on IgG1/FcγR interaction and ADCC activity." in: Biologicals : journal of the International Association of Biological Standardization, Vol. 58, pp. 16-21, (2019) (PubMed).
Hayes, Frostell, Cosgrave, Struwe, Potter, Davey, Karlsson, Anneren, Rudd: "Fc gamma receptor glycosylation modulates the binding of IgG glycoforms: a requirement for stable antibody interactions." in: Journal of proteome research, Vol. 13, Issue 12, pp. 5471-85, (2014) (PubMed).
Aliases for FCGR3B 蛋白
Fc fragment of IgG receptor IIIb (FCGR3B) 蛋白 Fc receptor, IgG, low affinity III (Fcgr3) 蛋白 Fc fragment of IgG receptor IIIa (FCGR3A) 蛋白 Fc-gamma RIII (FCGR3) 蛋白 CD16 蛋白 CD16b 蛋白 FCG3 蛋白 FCGR3 蛋白 FCR-10 蛋白 FCRIII 蛋白 FcRIII 蛋白 FCRIIIb 蛋白