(Fc Fragment of IgG, Low Affinity IIb, Receptor (CD32) (FCGR2B))
The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010].
Aoyama, Hashii, Tsukimura, Osumi, Harazono, Tada, Kiyoshi, Matsuda, Ishii-Watabe: "Effects of terminal galactose residues in mannose α1-6 arm of Fc-glycan on the effector functions of therapeutic monoclonal antibodies." in: mAbs, Vol. 11, Issue 5, pp. 826-836, (2020) (PubMed).
Simonov, Ivanov, Smolov, Abbasova, Piskunov, Poteryaev: "Control of therapeutic IgG antibodies galactosylation during cultivation process and its impact on IgG1/FcγR interaction and ADCC activity." in: Biologicals : journal of the International Association of Biological Standardization, Vol. 58, pp. 16-21, (2019) (PubMed).
Hayes, Frostell, Cosgrave, Struwe, Potter, Davey, Karlsson, Anneren, Rudd: "Fc gamma receptor glycosylation modulates the binding of IgG glycoforms: a requirement for stable antibody interactions." in: Journal of proteome research, Vol. 13, Issue 12, pp. 5471-85, (2014) (PubMed).
Sakamoto, Ito, Hatanaka, Soni, Mori, Sugimura: "Discovery and characterization of a peptide motif that specifically recognizes a non-native conformation of human IgG induced by acidic pH conditions." in: The Journal of biological chemistry, Vol. 284, Issue 15, pp. 9986-93, (2009) (PubMed).
Aliases for FCGR2B 蛋白
Fc fragment of IgG receptor IIb (FCGR2B) 蛋白 Fc fragment of IgG, low affinity IIb, receptor (CD32) (FCGR2B) 蛋白 Fc receptor, IgG, low affinity IIb (Fcgr2b) 蛋白 Fc fragment of IgG receptor IIb (Fcgr2b) 蛋白 low affinity immunoglobulin gamma Fc region receptor II (LOC100856270) 蛋白 AI528646 蛋白 CD32 蛋白 CD32B 蛋白 F630109E10Rik 蛋白 FCG2 蛋白 FCGR2 蛋白 Fcgr2 蛋白 Fcgr2a 蛋白 FCGR2B 蛋白 FcgRII 蛋白 Fcr-2 蛋白 Fcr-3 蛋白 FCRII 蛋白 FcRII 蛋白 Fc[g]RII 蛋白 IGFR2 蛋白 Ly-17 蛋白 Ly-m20 蛋白 LyM-1 蛋白 Lym-1 蛋白