(Fc Fragment of IgG, Low Affinity IIb, Receptor (CD32) (FCGR2B))
The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010].
Smith, Wietgrefe, Shang, Reilly, Southern, Perkey, Duan, Kohler, Müller, Robinson, Carlis, Li, Johnson, Haase: "Live simian immunodeficiency virus vaccine correlate of protection: immune complex-inhibitory Fc receptor interactions that reduce target cell availability." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 193, Issue 6, pp. 3126-33, (2014) (PubMed).
White, Chan, Roghanian, French, Mockridge, Tutt, Dixon, Ajona, Verbeek, Al-Shamkhani, Cragg, Beers, Glennie: "Interaction with Fc?RIIB is critical for the agonistic activity of anti-CD40 monoclonal antibody." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 187, Issue 4, pp. 1754-63, (2011) (PubMed).
McGaha, Sorrentino, Ravetch: "Restoration of tolerance in lupus by targeted inhibitory receptor expression." in: Science (New York, N.Y.), Vol. 307, Issue 5709, pp. 590-3, (2005) (PubMed).
Aliases for FCGR2B 抗体
Fc fragment of IgG receptor IIb (FCGR2B) 抗体 Fc fragment of IgG, low affinity IIb, receptor (CD32) (FCGR2B) 抗体 Fc receptor, IgG, low affinity IIb (Fcgr2b) 抗体 Fc fragment of IgG receptor IIb (Fcgr2b) 抗体 low affinity immunoglobulin gamma Fc region receptor II (LOC100856270) 抗体 AI528646 抗体 CD32 抗体 CD32B 抗体 F630109E10Rik 抗体 FCG2 抗体 FCGR2 抗体 Fcgr2 抗体 Fcgr2a 抗体 FCGR2B 抗体 FcgRII 抗体 Fcr-2 抗体 Fcr-3 抗体 FCRII 抗体 FcRII 抗体 Fc[g]RII 抗体 IGFR2 抗体 Ly-17 抗体 Ly-m20 抗体 LyM-1 抗体 Lym-1 抗体