(Fc Fragment of IgG, Low Affinity IIa, Receptor (CD32) (FCGR2A))
This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008].
Simonov, Ivanov, Smolov, Abbasova, Piskunov, Poteryaev: "Control of therapeutic IgG antibodies galactosylation during cultivation process and its impact on IgG1/FcγR interaction and ADCC activity." in: Biologicals : journal of the International Association of Biological Standardization, Vol. 58, pp. 16-21, (2019) (PubMed).
Hayes, Frostell, Cosgrave, Struwe, Potter, Davey, Karlsson, Anneren, Rudd: "Fc gamma receptor glycosylation modulates the binding of IgG glycoforms: a requirement for stable antibody interactions." in: Journal of proteome research, Vol. 13, Issue 12, pp. 5471-85, (2014) (PubMed).
Aliases for FCGR2A 蛋白
Fc fragment of IgG receptor IIa (FCGR2A) 蛋白 CD32 蛋白 CD32A 蛋白 CD32a 蛋白 CDw32 蛋白 FCG2 蛋白 FcGR 蛋白 FCGR2 蛋白 FCGR2A1 蛋白 IGFR2 蛋白