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Human FRS2 Protein expressed in Wheat germ - ABIN1354441
Krejci, Masri, Salazar, Farrington-Rock, Prats, Thompson, Wilcox: Bisindolylmaleimide I suppresses fibroblast growth factor-mediated activation of Erk MAP kinase in chondrocytes by preventing Shp2 association with the Frs2 and Gab1 adaptor proteins. in The Journal of biological chemistry 2007
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MiR (显示 MLXIP 蛋白)-4653-3p and its target gene FRS2 are may have roles in response of hormone receptor (显示 NR4A1 蛋白) positive breast cancer patients to tamoxifen
we report for the first time that PKD1 (显示 PKD1 蛋白) was tightly regulated by androgen at the transcriptional level in prostate cancer cells and was a novel androgen-repressed gene. Further analysis identified FRS2 as a novel mediator of androgen-induced PKD1 (显示 PKD1 蛋白) repression.
They also demonstrate the potential of overexpressed FRS2alpha as a biomarker for prostate cancer diagnosis, prognosis and response to therapies.
Results identify FRS2 as an oncogene (显示 RAB1A 蛋白) in a subset of high-grade serous ovarian cancers that harbor FRS2 amplifications.
Increased expression of FRS2alpha (and FGFR1 (显示 FGFR1 蛋白)) was associated with decreased progression-free survival among patients with metastatic renal cell carcinoma (显示 MOK 蛋白) treated with sorafenib.
The signaling complex appears to integrate the input from FGFR (显示 FGFR2 蛋白) and EphA4 (显示 EPHA4 蛋白), and release the output signal through FRS2alpha.
These results establish the Frs2alpha-Shp2 complex as the key mediator of FGF signaling in lens development.
The docking protein FRS2alpha is a critical regulator of VEGF (显示 VEGFA 蛋白) receptors signaling.
Patient with pigmentation disorders and vitiligo (显示 MITF 蛋白) show decreased expression of mRNA.
Data indicate that the FGFR (显示 FGFR2 蛋白)/FRS2 signaling axis was generally activated in about 75% of FRS2-positive high-grade liposarcomas.
FRS2alpha-mediated pathways are essential for the FGF15/FGF19-FGFR4 (显示 FGFR4 蛋白) signaling axis to control bile acid homeostasis.
Embryonic day 18.5 Six2Frs2alphaKO kidneys were hypoplastic and not cystic, postnatal day (P) 7 mutants had proximal tubular-derived cysts that nearly replaced the renal parenchyma by P21. Mutants had high proximal tubular proliferation rates and interstitial fibrosis, similar to known polycystic kidney disease models.
Fgfr (显示 FGFR2 蛋白) signaling in nephron progenitors appears to be mediated predominantly by Frs2alpha.
Analysis of a mutant Fgfr1 (显示 FGFR1 蛋白) allele, unable to bind to the adaptor protein, Frs2/3, indicates that Sox2 (显示 SOX2 蛋白) maintenance can be regulated by MAP kinase (显示 MAPK1 蛋白).
data from two models showed that FRS2 played different roles in the regulation of two activity levels of the ERK (显示 EPHB2 蛋白) pathway components in the epididymis.
Genetic evidence further supports that the formation of an Frs2alpha-Shp2 (显示 PTPN11 蛋白) complex and its recruitment to FGF receptors are crucial for downstream ERK (显示 EPHB2 蛋白) signaling in this process.
Frs2alpha enhances fibroblast growth factor-mediated survival and differentiation in lens development.
a novel signaling network containing FRS2, CAP and flotillin-1 (显示 FLOT1 蛋白)
FRS2alpha-mediated FGF signals suppress premature differentiation of cardiac stem cells through regulating autophagy activity.
The FGF signaling axis activates mTOR (显示 FRAP1 蛋白) via the FGF receptor (显示 FGFR2 蛋白) substrate 2alpha (FRS2alpha)-mediated PI3K/Akt (显示 AKT1 蛋白) pathway, and suppresses autophagy activity in MEFs.
Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3- kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
fibroblast growth factor receptor substrate 2
, FGFR signalling adaptor
, FGFR substrate 2
, FGFR-signaling adaptor SNT
, suc1-associated neurotrophic factor target 1