FBXW4 产品
(F-Box and WD Repeat Domain Containing 4 (FBXW4))
Categories
This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds\; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22. [provided by RefSeq, Jul 2008].
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Featured FBXW4 Categories
FBXW4 抗体
High quality antibodies with extensive validation data.
FBXW4 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
FBXW4 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended FBXW4 抗体
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Reactivity
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Cat. No.
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Datasheet
Reactivity
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Cat. No.
ABIN7152503
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
WB
Validations
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- (1)
Cat. No.
ABIN1881340
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400 μL
Datasheet
Datasheet
Reactivity
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Cat. No.
ABIN562867
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50 μL
Datasheet
Datasheet
Recommended FBXW4 ELISA试剂盒
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Analytical Method
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Cat. No.
ABIN6966623
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96 tests
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Quantitative Competition ELISA
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Cat. No.
ABIN1743136
Quantity
96 tests
Datasheet
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Sheep
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ABIN1774041
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96 tests
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Recommended FBXW4 蛋白
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Reactivity
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Cat. No.
ABIN1353871
Quantity
10 μg
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Source
Tobacco (Nicotiana tabacum)
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Cat. No.
ABIN3080125
Quantity
1 mg
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Datasheet
Reactivity
Mouse
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Cat. No.
ABIN3130394
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Datasheet
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Latest Publications for our FBXW4 Products
: "Frequency of genomic rearrangements involving the SHFM3 locus at chromosome 10q24 in syndromic and non-syndromic split-hand/foot malformation." in: American journal of medical genetics. Part A, Vol. 140, Issue 13, pp. 1375-83, (2006) (PubMed).: "The DNA sequence and comparative analysis of human chromosome 10. ..." in: Nature, Vol. 429, Issue 6990, pp. 375-81, (2004) (PubMed).
: "A genomic rearrangement resulting in a tandem duplication is associated with split hand-split foot malformation 3 (SHFM3) at 10q24. ..." in: Human molecular genetics, Vol. 12, Issue 16, pp. 1959-71, (2003) (PubMed).
: "cDNA cloning and expression analysis of new members of the mammalian F-box protein family." in: Genomics, Vol. 67, Issue 1, pp. 40-7, (2000) (PubMed).
Synonyms and alternative names related to FBXW4
F-box and WD repeat domain containing 4 (fbxw4), F-box and WD repeat domain containing 4 (FBXW4), F-box and WD repeat domain containing 4 (Fbxw4), F-box and WD-40 domain protein 4 (Fbxw4), dac, DAC, Dac, dactylin, dactylyn, FBW4, Fbw4, FBWD4, FBXW4, hag, hagoromo, SHFM3, SHSF3, wu:fk63g06Protein level used designations for FBXW4
- F-box/WD repeat-containing protein 4
- dactylaplasia
- fk63g06
- F-box and WD repeat domain containing 4
- F-box and WD-40 domain protein 4
- F-box and WD-40 domain-containing protein 4
- F-box/WD repeat protein 4
- dactylin
- F-box protein Fbw4
- protein hagoromo
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