ERVW-1 抗体
(Endogenous Retrovirus Group W, Member 1 (ERVW-1))
Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010].
Latest Publications for our ERVW-1 抗体
: "Regulation of the human endogenous retroviral Syncytin-1 and cell-cell fusion by the nuclear hormone receptors PPAR?/RXR? in placentogenesis." in: Journal of cellular biochemistry, Vol. 113, Issue 7, pp. 2383-96, (2012) (PubMed).
: "Is galectin-1 a trigger for trophoblast cell fusion?: the MAP-kinase pathway and syncytium formation in trophoblast tumour cells BeWo." in: Molecular human reproduction, Vol. 17, Issue 12, pp. 747-57, (2011) (PubMed).
: "Impaired cell fusion and differentiation in placentae from patients with intrauterine growth restriction correlate with reduced levels of HERV envelope genes." in: Journal of molecular medicine (Berlin, Germany), Vol. 88, Issue 11, pp. 1143-56, (2010) (PubMed).
: "Stimulation of syncytium formation in vitro in human trophoblast cells by galectin-1." in: Placenta, Vol. 31, Issue 9, pp. 825-32, (2010) (PubMed).
: "Is galectin-1 a trigger for trophoblast cell fusion?: the MAP-kinase pathway and syncytium formation in trophoblast tumour cells BeWo." in: Molecular human reproduction, Vol. 17, Issue 12, pp. 747-57, (2011) (PubMed).
: "Impaired cell fusion and differentiation in placentae from patients with intrauterine growth restriction correlate with reduced levels of HERV envelope genes." in: Journal of molecular medicine (Berlin, Germany), Vol. 88, Issue 11, pp. 1143-56, (2010) (PubMed).
: "Stimulation of syncytium formation in vitro in human trophoblast cells by galectin-1." in: Placenta, Vol. 31, Issue 9, pp. 825-32, (2010) (PubMed).
Aliases for ERVW-1 抗体
endogenous retrovirus group W member 1, envelope (ERVW-1) 抗体ENV 抗体
ENVW 抗体
ERVWE1 抗体
HERV-7q 抗体
HERV-W-ENV 抗体
HERV7Q 抗体
HERVW 抗体
HERVWENV 抗体
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