(Endoplasmic Reticulum To Nucleus Signaling 2 (ERN2))
Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.
Iwawaki, Hosoda, Okuda, Kamigori, Nomura-Furuwatari, Kimata, Tsuru, Kohno: "Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress." in: Nature cell biology, Vol. 3, Issue 2, pp. 158-64, (2001) (PubMed).
Niwa, Sidrauski, Kaufman, Walter: "A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response." in: Cell, Vol. 99, Issue 7, pp. 691-702, (2000) (PubMed).
Brewer, Diehl: "PERK mediates cell-cycle exit during the mammalian unfolded protein response." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 23, pp. 12625-30, (2000) (PubMed).