ERN2 抗体 (AA 841-890)
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Quick Overview for ERN2 抗体 (AA 841-890) (ABIN1533968)
抗原
See all ERN2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 841-890
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原理
- IREβ Antibody
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特异性
- IRE1α/β Polyclonal Antibody detects endogenous levels of IRE1α/β protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human ERN2. AA range:841-890
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亚型
- IgG
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anti-Endoplasmic Reticulum To Nucleus Signaling 2 (ERN2) antibody
ERN2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Endoplasmic Reticulum To Nucleus Signaling 2 (ERN2) (AA 39-72), (N-Term) antibodyERN2 适用: 人 WB 宿主: 兔 Polyclonal RB8519 unconjugated
anti-Endoplasmic Reticulum To Nucleus Signaling 2 (ERN2) (AA 517-919) antibodyERN2 适用: 人 ELISA, WB, FACS 宿主: 兔 Polyclonal unconjugated
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应用备注
- IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- ERN2 (Endoplasmic Reticulum To Nucleus Signaling 2 (ERN2))
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别名
- ERN2
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背景
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Synonyms: ERN2, IRE2, Serine/threonine-protein kinase/endoribonuclease IRE2, Endoplasmic reticulum-to-nucleus signaling 2, Inositol-requiring protein 2, hIRE2p, Ire1-beta, IRE1b
Background: catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:The kinase domain is activated by trans-autophosphorylation. Kinase activity is required for activation of the endoribonuclease domain.,function:Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.,similarity:Contains 1 KEN domain.,similarity:Contains 1 protein kinase domain.,
Gene Name: ERN2
Protein Name: Serine/threonine-protein kinase/endoribonuclease IRE2
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分子量
- 102 kDa
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基因ID
- 10595
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OMIM
- 604034
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UniProt
- Q76MJ5
抗原
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