电话:
+86 (0512) 65829739
传真:
+86 (010) 6788 5057
电子邮件:
orders@antibodies-online.cn

ERBB3 蛋白

(Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008].

37 results :

ERBB3 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
产品编号 ABIN7274801
 
ERBB3 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
产品编号 ABIN7274797
 
ERBB3 宿主: Cynomolgus, 猕猴 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
产品编号 ABIN7274795
 
ERBB3 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE, > 95 % as determined by HPLC
产品编号 ABIN7274802
 
ERBB3 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
产品编号 ABIN6961140
 
ERBB3 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
产品编号 ABIN1353017
 
ERBB3 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
产品编号 ABIN7124803
 
ERBB3 宿主: 人 宿主: Mammalian Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
产品编号 ABIN7538508
 
ERBB3 宿主: 人 宿主: Mammalian Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
产品编号 ABIN7538507
 
ERBB3 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 93 % as determined by SDS-PAGE Active
产品编号 ABIN7320073
 
ERBB3 宿主: 人 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
产品编号 ABIN7319879
 
ERBB3 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
产品编号 ABIN6938840
 
ERBB3 宿主: 小鼠 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
产品编号 ABIN7013406
 
ERBB3 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
产品编号 ABIN2720372
 
ERBB3 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by reduced SDS-PAGE. Active
产品编号 ABIN6933652
 
ERBB3 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
产品编号 ABIN6810022
 
ERBB3 宿主: 人 宿主: 人细胞 Recombinant > 95 % as determined by reducing SDS-PAGE.
产品编号 ABIN1945377
 
ERBB3 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
产品编号 ABIN7504352
 
ERBB3 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by reducing SDS-PAGE. Active
产品编号 ABIN7197658
 
ERBB3 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by reducing SDS-PAGE. Active
产品编号 ABIN7317968
 
  • 类型 Protein
    • Protein
  • 应用范围
    • SDS-PAGE (SDS)
    • Western Blotting (WB)
    • ELISA
    • Antibody Production (AbP)
    • Standard (STD)
    • Immunogen (Imm)
    • Positive Control (PC)
    • Activity Assay (AcA)
    • Affinity Purification (AP)
    • Antibody Array (AA)
    • Control (Ct)
  • 适用
    • Human
    • Mouse
    • Cynomolgus
    • Rat
    • Rhesus Monkey
  • 图像
  • Carrier free only
  • 抗体来源
    • HEK-293 Cells
    • Mammalian Cells
    • Escherichia coli (E. coli)
    • Human Cells
    • Insect Cells
    • Baculovirus infected Insect Cells
    • Insect cells (Sf9)
    • Wheat germ
    • Yeast
  • 抗原表位
    • AA 20-643
    • AA 20-641
    • AA 544-643
    • Transcript Variant 1
    • AA 1005-1230
    • AA 20-331
    • AA 21-331
    • AA 707-964
    • AA 709-966
    • AA 730-1065
    • Transcript Variant S
  • 标记
    • His tag
    • Fc Tag
    • Myc-DYKDDDDK Tag
    • mFc Tag
    • Biotin,His-Avi Tag
    • DYKDDDDK Tag
    • DYKDDDDK-His Tag
    • FITC,His tag
    • FITC,His-Avi Tag
    • GST tag
    • GST tag,His tag
    • His tag,AVI tag,Biotin
    • His-Avi Tag
    • His-Avi Tag,Biotin
    • His-Fc tag
    • Strep Tag
    • 非结合性
  • 蛋白类型
    • Recombinant
  • Format
    • Lyophilized
    • Liquid
  • 生物活性
    • Biologically Active
  • Supplier
    • antibodies-online
    • ACROBiosystems
    • OriGene
    • CUSABIO
    • ITSI-Biosciences

Latest Publications for our ERBB3 蛋白

DAgostino, Gentile, Ponziani, Di Vittorio, Dituri, Giannelli, Rossi, Marzullo, Giansanti, De Laurenzi, Iacobelli, Ippoliti, Capone, Sala: "EV20‑sss‑vc/MMAF, an HER‑3 targeting antibody‑drug conjugate displays antitumor activity in liver cancer." in: Oncology reports, Vol. 45, Issue 2, pp. 776-785, (2021) (PubMed).

Shinozaki, Hashimoto, Fukui, Uchiyama: "Efficient generation of single domain antibodies with high affinities and enhanced thermal stabilities." in: Scientific reports, Vol. 7, Issue 1, pp. 5794, (2019) (PubMed).

Capone, Lamolinara, DAgostino, Rossi, De Laurenzi, Iezzi, Iacobelli, Sala: "EV20-mediated delivery of cytotoxic auristatin MMAF exhibits potent therapeutic efficacy in cutaneous melanoma." in: Journal of controlled release : official journal of the Controlled Release Society, Vol. 277, pp. 48-56, (2019) (PubMed).

Sala, Rapposelli, Ghasemi, Piccolo, Traini, Capone, Rossi, Pelliccia, Di Risio, DEgidio, Tinari, Muraro, Iacobelli: "EV20, a Novel Anti-ErbB-3 Humanized Antibody, Promotes ErbB-3 Down-Regulation and Inhibits Tumor Growth In Vivo." in: Translational oncology, Vol. 6, Issue 6, pp. 676-84, (2014) (PubMed).

Nilvebrant, Astrand, Löfblom, Hober: "Development and characterization of small bispecific albumin-binding domains with high affinity for ErbB3." in: Cellular and molecular life sciences : CMLS, Vol. 70, Issue 20, pp. 3973-85, (2013) (PubMed).

Aliases for ERBB3 蛋白

erb-b2 receptor tyrosine kinase 3 (ERBB3) 蛋白
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (ERBB3) 蛋白
erb-b2 receptor tyrosine kinase 3 (Erbb3) 蛋白
c-erbB-3 蛋白
c-erbB3 蛋白
C76256 蛋白
ErbB-3 蛋白
Erbb-3 蛋白
ERBB3 蛋白
erbB3-S 蛋白
Erbb3r 蛋白
HER3 蛋白
Her3 蛋白
LCCS2 蛋白
MDA-BF-1 蛋白
nuc-ErbB3 蛋白
p45-sErbB3 蛋白
p85-sErbB3 蛋白
p180-ErbB3 蛋白
You are here:
Chat with us!