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ErbB2/Her2 蛋白

(Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008].

59 results :

ErbB2/Her2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
产品编号 ABIN7274799
 
ErbB2/Her2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
产品编号 ABIN7274796
 
ErbB2/Her2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
产品编号 ABIN7274800
 
ErbB2/Her2 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Pubmed 15 references
产品编号 ABIN2181214
 
ErbB2/Her2 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
产品编号 ABIN7274794
 
ErbB2/Her2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Pubmed 2 references
产品编号 ABIN1353011
 
ErbB2/Her2 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
产品编号 ABIN6964074
 
ErbB2/Her2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
产品编号 ABIN7274804
 
ErbB2/Her2 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Pubmed 2 references
产品编号 ABIN2181216
 
ErbB2/Her2 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Pubmed 2 references
产品编号 ABIN6809903
 
ErbB2/Her2 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
产品编号 ABIN7013682
 
ErbB2/Her2 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Pubmed 1 reference
产品编号 ABIN5954984
 
ErbB2/Her2 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by reduced SDS-PAGE. Active
Pubmed 2 references
产品编号 ABIN2444140
 
ErbB2/Her2 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
产品编号 ABIN7124801
 
ErbB2/Her2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
产品编号 ABIN1353013
 
ErbB2/Her2 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 85% by SDS-PAGE SDS
产品编号 ABIN7281248
 
ErbB2/Her2 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE
产品编号 ABIN7321222
 
ErbB2/Her2 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 85 % as determined by SDS-PAGE
产品编号 ABIN7321223
 
ErbB2/Her2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE
产品编号 ABIN7319994
 
ErbB2/Her2 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 92 % as determined by SDS-PAGE Active
产品编号 ABIN7321221
 
  • 类型 Protein
    • Protein
  • 应用范围
    • Western Blotting (WB)
    • SDS-PAGE (SDS)
    • ELISA
    • Immunogen (Imm)
    • Positive Control (PC)
    • Antibody Production (AbP)
    • Standard (STD)
    • Affinity Purification (AP)
    • Antibody Array (AA)
    • Activity Assay (AcA)
    • Enzyme Immunoassay (EIA)
    • Functional Studies (Func)
  • 适用
    • Human
    • Rat
    • Mouse
    • Cynomolgus
    • Rabbit
  • 论文引用
  • 图像
  • Preservative free only
  • Carrier free only
  • 抗体来源
    • HEK-293 Cells
    • Escherichia coli (E. coli)
    • Mammalian Cells
    • Wheat germ
    • Baculovirus infected Insect Cells
    • Human Cells
    • Insect Cells
    • Insect cells (Sf9)
    • Yeast
  • 抗原表位
    • AA 23-652
    • Transcript Variant 1
    • AA 1-1255
    • AA 120-749
    • AA 153-598
    • AA 22-121
    • AA 23-372
    • AA 23-510
    • AA 23-653
    • AA 23-654
    • AA 376-578
    • AA 377-579
    • AA 380-582
    • AA 4-656
    • AA 489-630
    • AA 498-648
    • AA 511-630
    • AA 67-323
    • Extracellular
    • Transcript Variant 2
    • partial
  • 标记
    • His tag
    • Fc Tag
    • 非结合性
    • GST tag
    • His tag,AVI tag,Biotin
    • His tag,GST tag
    • His-Avi Tag,Biotin
    • Myc-DYKDDDDK Tag
    • APC,His tag
    • Alexa Fluor 488,His tag
    • Alexa Fluor 555,His tag
    • Alexa Fluor 647,His tag
    • Biotin
    • DYKDDDDK Tag
    • DYKDDDDK-His Tag
    • FITC,Fc Tag
    • Fc Tag,His tag
    • His tag,Biotin
    • His tag,FITC
    • His tag,PE
    • His-Avi Tag
    • PE,His tag
    • Strep Tag
  • 蛋白类型
    • Recombinant
  • Format
    • Lyophilized
    • Liquid
  • 生物活性
    • Biologically Active
  • Supplier
    • antibodies-online
    • ACROBiosystems
    • OriGene
    • Signalway
    • CUSABIO
    • FabGennix
    • ProSci

Latest Publications for our ErbB2/Her2 蛋白

Farràs, Román, Camps, Miret, Martínez, Pujol, Casablancas, Cairó: "Heavy chain dimers stabilized by disulfide bonds are required to promote in vitro assembly of trastuzumab." in: BMC molecular and cell biology, Vol. 21, Issue 1, pp. 2, (2020) (PubMed).

Murakami, Matsumoto, Kanamori: "Constructive approach for synthesis of a functional IgG using a reconstituted cell-free protein synthesis system." in: Scientific reports, Vol. 9, Issue 1, pp. 671, (2020) (PubMed).

Hao, Yu, Bai, McBride, Huang: "Cryo-EM Structure of HER2-trastuzumab-pertuzumab complex." in: PLoS ONE, Vol. 14, Issue 5, pp. e0216095, (2020) (PubMed).

Turner, Kilgour, Stine, Daniele, Menegatti: "Dual-Affinity Ratiometric Quenching (DARQ) Assay for the Quantification of Therapeutic Antibodies in CHO-S Cell Culture Fluids." in: Analytical chemistry, Vol. 92, Issue 24, pp. 16274-16283, (2020) (PubMed).

Hutterer, Polozova, Kuhns, McBride, Cao, Liu: "Assessing Analytical and Functional Similarity of Proposed Amgen Biosimilar ABP 980 to Trastuzumab." in: BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, Vol. 33, Issue 3, pp. 321-333, (2019) (PubMed).

Hussack, Raphael, Lowden, Henry: "Isolation and characterization of camelid single-domain antibodies against HER2." in: BMC research notes, Vol. 11, Issue 1, pp. 866, (2019) (PubMed).

Shinozaki, Hashimoto, Fukui, Uchiyama: "Efficient generation of single domain antibodies with high affinities and enhanced thermal stabilities." in: Scientific reports, Vol. 7, Issue 1, pp. 5794, (2019) (PubMed).

Wang, Forterre, Zhao, Frimannsson, Delcayre, Antes, Efron, Jeffrey, Pegram, Matin: "Anti-HER2 scFv-Directed Extracellular Vesicle-Mediated mRNA-Based Gene Delivery Inhibits Growth of HER2-Positive Human Breast Tumor Xenografts by Prodrug Activation." in: Molecular cancer therapeutics, Vol. 17, Issue 5, pp. 1133-1142, (2019) (PubMed).

Mortensen, Skovsgaard, Okholm, Scavenius, Dupont, Rosen, Enghild, Kjems, Gothelf: "Small-Molecule Probes for Affinity-Guided Introduction of Biocompatible Handles on Metal-Binding Proteins." in: Bioconjugate chemistry, Vol. 29, Issue 9, pp. 3016-3025, (2019) (PubMed).

Vivier, Sharma, Adumeau, Rodriguez, Fung, Zeglis: "The Impact of FcγRI Binding on ImmunoPET." in: Journal of nuclear medicine : official publication, Society of Nuclear Medicine, (2019) (PubMed).

Aliases for ErbB2/Her2 蛋白

erb-b2 receptor tyrosine kinase 2 (ERBB2) 蛋白
erb-b2 receptor tyrosine kinase 2 (Erbb2) 蛋白
erb-b2 receptor tyrosine kinase 2 (erbb2) 蛋白
c-erbB2 蛋白
c-neu 蛋白
CD340 蛋白
erb2 蛋白
Erbb-2 蛋白
HER-2 蛋白
HER-2/neu 蛋白
HER2 蛋白
mKIAA3023 蛋白
MLN 19 蛋白
NEU 蛋白
Neu 蛋白
NGL 蛋白
TKR1 蛋白
wu:fv70f10 蛋白
zgc:63601 蛋白
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