ErbB2/Her2 Protein (AA 23-652) (His tag,Biotin)
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- 抗原 See all ErbB2/Her2 蛋白
- ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 23-652
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This ErbB2/Her2 protein is labelled with His tag,Biotin.
- 品牌
- MABSol®,UltraLys
- 序列
- AA 23-652
- 特异性
- The primary amines in the side chains of lysine residues and the N-terminus of the protein are conjugated with biotins using standard chemical labeling method. A standard biotin reagent (13.5 angstroms) is used in this product.
- 产品特性
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 70.2 kDa. The protein migrates as 110-115 kDa on a SDS-PAGE gel under reducing (R) condition due to glycosylation.
- 纯度
- >95 % as determined by reduced SDS-PAGE.
- 内毒素水平
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product ErbB2/Her2 蛋白
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Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 23-652) protein (His-Avi Tag)
ErbB2/Her2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 23-652) protein (Fc Tag)ErbB2/Her2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) protein (His-Avi Tag,Biotin)ErbB2/Her2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 23-652) (Active) protein (His tag)ErbB2/Her2 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 23-652) protein (His tag)ErbB2/Her2 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 1-1255) protein (GST tag)ErbB2/Her2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 489-630) protein (His-Avi Tag,Biotin)ErbB2/Her2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 676-1255) (Active) protein (GST tag)ErbB2/Her2 宿主: 人 宿主: Insect cells (Sf21) Recombinant SDS, Func Active
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 679-1255) (Active) protein (His-GST)ErbB2/Her2 宿主: 人 宿主: Insect cells (Sf9) Recombinant SDS, Func Active
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 23-652) (Active) proteinErbB2/Her2 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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- 说明
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A chemically labeled biotinylated protein with ultra sensitivity.
The product is produced using a chemical labeling approach. The primary amines in the side chains of lysine residues and the N-terminus of protein are conjugated with biotins.
Chemical labeling usually results in multiple biotin attachment on a single protein molecule, which could potentially lead to higher detection sensitivity. - 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- PBS, pH 7.4
- 注意事项
- Please avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- Lyophilized Protein should be stored at -20 °C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20 °C or -70 °C. Avoid repeated freeze-thaw cycles.
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: "Small-Molecule Probes for Affinity-Guided Introduction of Biocompatible Handles on Metal-Binding Proteins." in: Bioconjugate chemistry, Vol. 29, Issue 9, pp. 3016-3025, (2019) (PubMed).
: "The Impact of FcγRI Binding on ImmunoPET." in: Journal of nuclear medicine : official publication, Society of Nuclear Medicine, (2019) (PubMed).
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: "Small-Molecule Probes for Affinity-Guided Introduction of Biocompatible Handles on Metal-Binding Proteins." in: Bioconjugate chemistry, Vol. 29, Issue 9, pp. 3016-3025, (2019) (PubMed).
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- 抗原
- ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
- 别名
- Her2 (ErbB2/Her2 产品)
- 别名
- CD340 Protein, HER-2 Protein, HER-2/neu Protein, HER2 Protein, MLN 19 Protein, NEU Protein, NGL Protein, TKR1 Protein, Erbb-2 Protein, Neu Protein, c-erbB2 Protein, c-neu Protein, mKIAA3023 Protein, wu:fv70f10 Protein, zgc:63601 Protein, erb2 Protein, erb-b2 receptor tyrosine kinase 2 Protein, ERBB2 Protein, Erbb2 Protein, erbb2 Protein
- 背景
- Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2,HER-2 /neu, NEU, NGL,TKR1 and c-erb B2,and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. Approximately 30 % of breast cancers have an amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer, communication at the neuromuscular junction and regulation of cell growth and differentiation .
- 分子量
- 70.2 kDa
- NCBI登录号
- NP_004439
- 途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development
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