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Generation of mature miR (显示 MYLIP 蛋白)-26b is activated during neurogenesis, where it suppresses Ctdsp2 protein expression and is required for neuronal cell differentiation in vivo
CTDSP2 induces p21(Cip1/Waf1 (显示 CDKN1A 蛋白)) through increasing the activity of Ras.
These results suggest that SCP2 is involved in promoter clearance during steroid-activated transcription.
SCP2 acts as a phosphatase for regulatory phosphorylations in the linker region of Smad1 (显示 GARS 蛋白) and Smad2 (显示 SMAD2 蛋白)
Preferentially catalyzes the dephosphorylation of 'Ser- 5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
, CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
, nuclear LIM interactor-interacting factor 2
, NLI-interacting factor 2
, conserved gene amplified in osteosarcoma
, protein OS-4
, small C-terminal domain phosphatase 2
, small CTD phosphatase 2
, nuclear LIM interactor-interacting factor 2 (NLI-interacting factor 2) (Protein OS-4)
, nuclear LIM interactor-interacting factor 2-like