The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation. [provided by RefSeq, Jul 2008].
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: "Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells." in: Nature methods, Vol. 10, Issue 4, pp. 315-23, (2013) (PubMed).
Kobayashi, Tanaka, Asao, Miura, Kyuuma, Semura, Ishii, Sugamura: "Hrs, a mammalian master molecule in vesicular transport and protein sorting, suppresses the degradation of ESCRT proteins signal transducing adaptor molecule 1 and 2." in: The Journal of biological chemistry, Vol. 280, Issue 11, pp. 10468-77, (2005) (PubMed).
Pandey, Fernandez, Steen, Blagoev, Nielsen, Roche, Mann, Lodish: "Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways." in: The Journal of biological chemistry, Vol. 275, Issue 49, pp. 38633-9, (2001) (PubMed).
Aliases for STAM2 抗体
signal transducing adaptor molecule 2 (STAM2) 抗体 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 (Stam2) 抗体 signal transducing adaptor molecule 2 (Stam2) 抗体 signal transducing adaptor molecule 2 S homeolog (stam2.S) 抗体 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 (stam2) 抗体 signal transducing adaptor molecule 2 (stam2) 抗体 1200004O12Rik 抗体 5730456G07Rik 抗体 BB145015 抗体 Hbp 抗体 MGC52950 抗体 stam2 抗体 STAM2A 抗体 STAM2B 抗体 zgc:103628 抗体