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EGLN3 蛋白

(Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))
Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. ELGN3 is the most important isozyme in limiting physiological activation of HIFs (particularly HIF2A) in hypoxia. Also hydroxylates PKM2 in hypoxia, limiting glycolysis. Under normoxia, hydroxylates and regulates the stability of ADRB2. Regulator of cardiomyocyte and neuronal apoptosis. In cardiomyocytes, inhibits the anti-apoptotic effect of BCL2 by disrupting the BAX-BCL2 complex. In neurones, has a NGF-induced proapoptotic effect, probably through regulating CASP3 activity. Also essential for hypoxic regulation of neutrophilic inflammation.

10 results :

custom-made EGLN3 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
产品编号 ABIN7564777
 
custom-made EGLN3 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
产品编号 ABIN7553810
 
EGLN3 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
产品编号 ABIN7122748
 
EGLN3 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
产品编号 ABIN1352449
 
EGLN3 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant SDS, ELISA, WB
产品编号 ABIN7576753
 
EGLN3 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant SDS Active
产品编号 ABIN2129051
 
custom-made EGLN3 宿主: 小鼠 宿主: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). SDS, ELISA, WB
产品编号 ABIN3136771
 
custom-made EGLN3 宿主: 人 宿主: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). SDS, ELISA, WB
产品编号 ABIN3092387
 
EGLN3 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
产品编号 ABIN2720029
 
EGLN3 宿主: 小鼠 宿主: 大肠杆菌(E. Coli) Recombinant > 90 % SDS
产品编号 ABIN5712938
 
  • 类型 Protein
    • Protein
  • 应用范围
    • ELISA
    • SDS-PAGE (SDS)
    • Western Blotting (WB)
    • Affinity Purification (AP)
    • Antibody Array (AA)
    • Antibody Production (AbP)
    • Standard (STD)
  • 适用
    • Human
    • Mouse
  • 图像
  • Carrier free only
  • 抗体来源
    • Escherichia coli (E. coli)
    • HEK-293 Cells
    • Cell-free protein synthesis (CFPS)
    • Wheat germ
  • 抗原表位
    • AA 1-239
    • AA 2-239
  • 标记
    • His tag
    • Strep Tag
    • GST tag
    • Myc-DYKDDDDK Tag
    • 非结合性
  • 蛋白类型
    • Recombinant
  • Format
    • Liquid
    • Lyophilized
  • 生物活性
    • Biologically Active
  • Grade
    • custom-made
  • Supplier
    • antibodies-online
    • OriGene
    • Signalway

Aliases for EGLN3 蛋白

egl-9 family hypoxia-inducible factor 3 (egln3) 蛋白
egl-9 family hypoxia inducible factor 3 (EGLN3) 蛋白
egl-9 family hypoxia-inducible factor 3 L homeolog (egln3.L) 蛋白
egl-9 family hypoxia-inducible factor 3 (Egln3) 蛋白
2610021G09Rik 蛋白
AI505553 蛋白
AI648162 蛋白
EGLN3 蛋白
Hif-p4h-3 蛋白
HIFP4H3 蛋白
HIFPH3 蛋白
PHD-3 蛋白
phd3 蛋白
PHD3 蛋白
Phd3 蛋白
SM-20 蛋白
wu:fj78a08 蛋白
zgc:77019 蛋白
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