Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It lacks mannosidase activity.
Molinari, Calanca, Galli, Lucca, Paganetti: "Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle." in: Science (New York, N.Y.), Vol. 299, Issue 5611, pp. 1397-400, (2003) (PubMed).
Nagase, Seki, Ishikawa, Ohira, Kawarabayasi, Ohara, Tanaka, Kotani, Miyajima, Nomura: "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 3, Issue 5, pp. 321-9, 341-54, (1997) (PubMed).
Aliases for EDEM1 抗体
ER degradation enhancer, mannosidase alpha-like 1 (edem1) 抗体 ER degradation enhancing alpha-mannosidase like protein 1 (edem1) 抗体 ER degradation enhancing alpha-mannosidase like protein 1 (EDEM1) 抗体 ER degradation-enhancing alpha-mannosidase-like protein 1 (LOC100637820) 抗体 ER degradation enhancing alpha-mannosidase like protein 1 L homeolog (edem1.L) 抗体 ER degradation enhancer, mannosidase alpha-like 1 (Edem1) 抗体 ER degradation enhancing alpha-mannosidase like protein 1 (Edem1) 抗体 A130059K23Rik 抗体 edem 抗体 EDEM 抗体 EDEM1 抗体 mKIAA0212 抗体 RGD1563633 抗体 zgc:55816 抗体