E2F4 产品
(E2F Transcription Factor 4, P107/p130-Binding (E2F4))
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The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq, Jul 2008].
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Featured E2F4 Categories
Recommended E2F4 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
ELISA, WB, IHC (p)
Validations
- (5)
Cat. No.
ABIN3187838
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Monkey, Mouse, Rat
Application
ELISA, WB, IHC, IF, ICC
Validations
- (4)
Cat. No.
ABIN6261411
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, WB
Validations
- (3)
Cat. No.
ABIN560681
Quantity
100 μg
Datasheet
Datasheet
Recommended E2F4 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6216586
Quantity
96 tests
Datasheet
Datasheet
Recommended E2F4 蛋白
Latest Publications for our E2F4 Products
: "ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer." in: Nature communications, Vol. 10, Issue 1, pp. 4632, (2019) (PubMed).: "Nerve growth factor-induced cell cycle reentry in newborn neurons is triggered by p38MAPK-dependent E2F4 phosphorylation." in: Molecular and cellular biology, Vol. 32, Issue 14, pp. 2722-37, (2012) (PubMed).
: "Peroxisome proliferator-activated receptor β/δ cross talks with E2F and attenuates mitosis in HRAS-expressing cells." in: Molecular and cellular biology, Vol. 32, Issue 11, pp. 2065-82, (2012) (PubMed).
Synonyms and alternative names related to E2F4
E2F transcription factor 4 (E2F4), E2F transcription factor 4 (E2f4), E2F transcription factor 4 S homeolog (e2f4.S), E2F transcription factor 4 (e2f4), 2010111M04Rik, AI427446, E2F-4, e2f-4, E2F4, fb72f07, wu:fb72f07, wu:fe05f06, zgc:63815Protein level used designations for E2F4
- p107/p130-binding protein
- transcription factor E2F4
- E2F-4
- E2F transcription factor 4, p107/p130-binding
- E2F transcription factor 4
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