DUSP10 抗体
(Dual Specificity Phosphatase 10 (DUSP10))
Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique\; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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53 results
DUSP10
适用: 人, 小鼠
WB, IF (cc), IF (p)
宿主: 兔
Polyclonal
AbBy Fluor® 594
Latest Publications for our DUSP10 抗体
: "Identification of the MEK1(F129L) activating mutation as a potential mechanism of acquired resistance to MEK inhibition in human cancers carrying the B-RafV600E mutation." in: Cancer research, Vol. 71, Issue 16, pp. 5535-45, (2011) (PubMed).: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).
: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, (2009) (PubMed).
: "Asbestos-induced MKP-3 expression augments TNF-alpha gene expression in human monocytes." in: American journal of respiratory cell and molecular biology, Vol. 39, Issue 1, pp. 113-23, (2008) (PubMed).
: "Several dual specificity phosphatases coordinate to control the magnitude and duration of JNK activation in signaling response to oxidative stress." in: The Journal of biological chemistry, Vol. 282, Issue 39, pp. 28395-407, (2007) (PubMed).
: "JAMP, a Jun N-terminal kinase 1 (JNK1)-associated membrane protein, regulates duration of JNK activity." in: Molecular and cellular biology, Vol. 25, Issue 19, pp. 8619-30, (2005) (PubMed).
: "MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases." in: Oncogene, Vol. 18, Issue 50, pp. 6981-8, (2000) (PubMed).
: "Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5." in: The Journal of biological chemistry, Vol. 274, Issue 28, pp. 19949-56, (1999) (PubMed).
: "Role of macrophage oxidative burst in the action of anthrax lethal toxin." in: Molecular medicine (Cambridge, Mass.), Vol. 1, Issue 1, pp. 7-18, (1996) (PubMed).
Aliases for DUSP10 抗体
dual specificity phosphatase 10 (DUSP10) 抗体dual specificity phosphatase 10 (Dusp10) 抗体
2610306G15Rik 抗体
AI158871 抗体
DUSP10 抗体
MKP-5 抗体
Mkp-5 抗体
MKP5 抗体
Mkp5 抗体
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