This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. [provided by RefSeq, Jul 2008].
Li, Armando, Yu, Escano, Mueller, Asico, Pascua, Lu, Wang, Villar, Jones, Wang, Periasamy, Lau, Soares-da-Silva, Creswell, Guillemette, Sibley, Eisner, Gildea, Felder, Jose: "Dopamine 5 receptor mediates Ang II type 1 receptor degradation via a ubiquitin-proteasome pathway in mice and human cells." in: The Journal of clinical investigation, Vol. 118, Issue 6, pp. 2180-9, (2008) (PubMed).
Lowe, Kirley, Hawi, Sham, Wickham, Kratochvil, Smith, Lee, Levy, Kent, Middle, Rohde, Roman, Tahir, Yazgan, Asherson, Mill, Thapar, Payton, Todd, Stephens, Ebstein, Manor, Barr, Wigg, Sinke et al.: "Joint analysis of the DRD5 marker concludes association with attention-deficit/hyperactivity disorder confined to the predominantly inattentive and combined subtypes. ..." in: American journal of human genetics, Vol. 74, Issue 2, pp. 348-56, (2004) (PubMed).
Luedtke, Griffin, Conroy, Jin, Pinto, Sesack: "Immunoblot and immunohistochemical comparison of murine monoclonal antibodies specific for the rat D1a and D1b dopamine receptor subtypes." in: Journal of neuroimmunology, Vol. 101, Issue 2, pp. 170-87, (1999) (PubMed).