The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. In contrast to other DOK family proteins, this protein does not interact with RASGAP. [provided by RefSeq, Jul 2008].
Pan, Zhang, Liu, Shu, Yin, Yuan, Qiang, Peng: "Dok5 is involved in the signaling pathway of neurotrophin-3 against TrkC-induced apoptosis." in: Neuroscience letters, Vol. 553, pp. 46-51, (2013) (PubMed).
Favre, Gérard, Clauzier, Pontarotti, Olive, Nunès: "DOK4 and DOK5: new Dok-related genes expressed in human T cells." in: Genes and immunity, Vol. 4, Issue 1, pp. 40-5, (2003) (PubMed).
Cai, Dhe-Paganon, Melendez, Lee, Shoelson: "Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5." in: The Journal of biological chemistry, Vol. 278, Issue 28, pp. 25323-30, (2003) (PubMed).
Aliases for DOK5 抗体
docking protein 5 (DOK5) 抗体 Docking protein 5 (dok5) 抗体 docking protein 5 (Dok5) 抗体 2700055C10Rik 抗体 C20orf180 抗体 RGD1562846 抗体