MCM4 蛋白 (MCM4)产品概述

Full name:: Minichromosome Maintenance Deficient 4 蛋白 (MCM4)

在www.antibodies-online.cn可供6 Minichromosome Maintenance Deficient 4 (MCM4) 蛋白的3不同的供货商。再加上，我们可以发MCM4 抗体 (126) 和 MCM4 试剂盒 (4)和数多这个蛋白质的别的产品。总共152 MCM4产品已列进来了。

别名:: 19G, AI325074, AU045576, cb1025, Cdc21, CDC54, fc12c09, fj85g09, hCdc21, hm:zeh1616, mcdc21, Mcmd4, mKIAA4003, NKCD, NKGCD, P1-CDC21, wu:fc12c09, wu:fj85g09, zeh1616

列出全部蛋白	基因	基因ID	UniProt
	MCM4	4173	P33991
大鼠 MCM4	MCM4	29728
	MCM4	17217	P49717
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Human MCM4 Protein expressed in Wheat germ - ABIN1310553 : Henderson, Hall, Prpic, Hessling, Parker, Sampson, Simkins, Brough, Dixon, Lenz, Knapp, Murphy, Taylor, Fischer, Malinowski: The selection and characterization of antibodies to minichromosome maintenance proteins that highlight cervical dysplasia. in Journal of immunological methods 2011 (PubMed)

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Human Minichromosome Maintenance Deficient 4 (MCM4) interaction partners

MCM4 and MCM7 (显示 MCM7 蛋白) expression is significantly correlated with Ki-67 (显示 MKI67 蛋白), Bmi1 (显示 BMI1 蛋白), and cyclin E (显示 CCNE1 蛋白) expression in esophageal adenocarcinoma, squamous cell carcinoma and precancerous lesions.
This MCM4 mutation affected human MCM4/6/7 complex formation, since the complex containing the mutant MCM4 protein is unstable and the mutant MCM4 protein is tend to be degraded.
We did not find any evidence of augmented response to a short-term (48 h) cisplatin treatment in these MCM4-deficient cells. However, MCM4-/HPV16+ SiHa cells cannot withstand a prolonged treatment (up to 5 days) of even a sublethal dosage of cisplatin
Purified MCM4/6/7 complex containing the G364R MCM4 exhibited similar levels of single-stranded DNA binding and ATPase activities to the complex containing wild-type MCM4
Mutant p53 (显示 TP53 蛋白) depletion profoundly influenced PARP1 (显示 PARP1 蛋白) localization and increased the level of PCNA (显示 PCNA 蛋白) and MCM4 proteins.
Of the total, the deregulation of several genes (CDK1 (显示 CDK1 蛋白), CDK2 (显示 CDK2 蛋白), CDK4 (显示 CDK4 蛋白), MCM2 (显示 MCM2 蛋白), MCM3 (显示 MCM3 蛋白), MCM4, EIF3a (显示 EIF6 蛋白) and RPN2 (显示 PSMD1 蛋白)) were potentially associated with disease development and progression.
Mcm2-7 (显示 MCM2 蛋白) loads onto origins during initiation as a double hexamer, yet does not act as a double-stranded DNA pump during elongation.
Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta) protein attenuates vascular lesion formation by inhibition of chromatin loading of minichromosome maintenance complex in smooth muscle cells
point mutation of MCM4 perturbs proper interaction with MCM6 (显示 MCM6 蛋白) to affect complex formation of MCM4/6/7 that is a core structure of MCM2-7 (显示 MCM2 蛋白) complex
Mutations in MCM4/PRKDC (显示 PRKDC 蛋白) represent a novel cause of DNA breakage and NK cell deficiency.

Mouse (Murine) Minichromosome Maintenance Deficient 4 (MCM4) interaction partners

Together, these data support a model in which chromosomal abnormalities in Sdl mice result from the ability of MCM4(D573H) to incorporate into MCM complexes and render them inactive.
Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta) protein attenuates vascular lesion formation by inhibition of chromatin loading of minichromosome maintenance complex in smooth muscle cells
partial MCM4 deficiency results in a genetic syndrome of growth retardation with adrenal insufficiency and selective NK deficiency
MCM4 mutation may have a role in adrenal failure, short stature, and natural killer cell deficiency
role of subunits in DNA helicase acdtivity
Substrate preference and helicase actions of mouse MCM4/6/7 helicase complexes.
MCM4 phosphorylation by Cdc7 (显示 CDC7 蛋白) kinase facilitates its interaction with Cdc45 (显示 CDC45 蛋白) on chromatin
Hypomorphic alleles of Mcm4 may increase breast cancer risk.
Loss of one allele of cdc2l (显示 CDK13 蛋白) genefacilitates carcinogen-induced skin carcinogenesis in vivo.
Mcm4(Chaos3) mutation appears to destabilize the MCM2-7 (显示 MCM2 蛋白) complex, causing impaired DNA replication and may have a causative role in cancer development.

蛋白简介MCM4

蛋白简介

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.

Alternative names and synonyms associated with MCM4

minichromosome maintenance complex component 4 (mcm4)
minichromosome maintenance complex component 4 (MCM4)
minichromosome maintenance complex component 4 (Mcm4)

19G 蛋白
AI325074 蛋白
AU045576 蛋白
cb1025 蛋白
Cdc21 蛋白
CDC54 蛋白
fc12c09 蛋白
fj85g09 蛋白
hCdc21 蛋白
hm:zeh1616 蛋白
mcdc21 蛋白
Mcmd4 蛋白
mKIAA4003 蛋白
NKCD 蛋白
NKGCD 蛋白
P1-CDC21 蛋白
wu:fc12c09 蛋白
wu:fj85g09 蛋白
zeh1616 蛋白

Protein level used designations for MCM4

DNA replication licensing factor mcm4 , MCM4 minichromosome maintenance deficient 4 , minichromosome maintenance protein 4 , DNA replication licensing factor MCM4 , CDC21 homolog , homolog of S. pombe cell devision cycle 21 , minichromosome maintenance deficient 4 , mini chromosome maintenance deficient 4 homolog , minichromosome maintenance deficient 4 homolog , P1-CDC21

GENE ID	SPECIES
448137	Xenopus (Silurana) tropicalis
337598	Danio rerio
4173	Homo sapiens
426764	Gallus gallus
477871	Canis lupus familiaris
504367	Bos taurus
29728	Rattus norvegicus
17217	Mus musculus

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Show all Minichromosome Maintenance Deficient 4 蛋白 (MCM4) with Pubmed References

Human Minichromosome Maintenance Deficient 4 (MCM4) interaction partners

Mouse (Murine) Minichromosome Maintenance Deficient 4 (MCM4) interaction partners

蛋白简介

Alternative names and synonyms associated with MCM4

Protein level used designations for MCM4