MCM4 蛋白

蛋白简介

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.

Alternative names and synonyms associated with MCM4

• minichromosome maintenance complex component 4 (mcm4) 抗体
• minichromosome maintenance complex component 4 (MCM4) 抗体
• minichromosome maintenance complex component 4 (Mcm4) 抗体

• 19G 抗体
• AI325074 抗体
• AU045576 抗体
• cb1025 抗体
• Cdc21 抗体
• 显示所有的同义词和别名
• CDC54 抗体
• fc12c09 抗体
• fj85g09 抗体
• hCdc21 抗体
• hm:zeh1616 抗体
• mcdc21 抗体
• Mcmd4 抗体
• mKIAA4003 抗体
• NKCD 抗体
• NKGCD 抗体
• P1-CDC21 抗体
• wu:fc12c09 抗体
• wu:fj85g09 抗体
• zeh1616 抗体

Protein level used designations for MCM4

DNA replication licensing factor mcm4 , MCM4 minichromosome maintenance deficient 4 , minichromosome maintenance protein 4 , DNA replication licensing factor MCM4 , CDC21 homolog , homolog of S. pombe cell devision cycle 21 , minichromosome maintenance deficient 4 , mini chromosome maintenance deficient 4 homolog , minichromosome maintenance deficient 4 homolog , P1-CDC21