DKK2 抗体
(Dickkopf 2 Homolog (DKK2))
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008].
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Latest Publications for our DKK2 抗体
: "DKK2 mediates osteolysis, invasiveness, and metastatic spread in Ewing sarcoma." in: Cancer research, Vol. 73, Issue 2, pp. 967-77, (2013) (PubMed).: "Epigenetic silencing of DKK2 and Wnt signal pathway components in human ovarian carcinoma." in: Carcinogenesis, Vol. 33, Issue 12, pp. 2334-43, (2012) (PubMed).
: "Expression pattern of REIC/Dkk-3 in various cell types and the implications of the soluble form in prostatic acinar development." in: International journal of oncology, Vol. 37, Issue 6, pp. 1495-501, (2011) (PubMed).
: "Wnt antagonist gene DKK2 is epigenetically silenced and inhibits renal cancer progression through apoptotic and cell cycle pathways." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 18, pp. 5678-87, (2009) (PubMed).
: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ..." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, (2003) (PubMed).
: "Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins." in: Molecular and cellular biology, Vol. 22, Issue 17, pp. 6100-10, (2002) (PubMed).
: "Functional and structural diversity of the human Dickkopf gene family." in: Gene, Vol. 238, Issue 2, pp. 301-13, (1999) (PubMed).
Aliases for DKK2 抗体
dickkopf WNT signaling pathway inhibitor 2 (DKK2) 抗体dickkopf WNT signaling pathway inhibitor 2 (Dkk2) 抗体
dickkopf WNT signaling pathway inhibitor 2 (dkk2) 抗体
DKK-2 抗体
Dkk4 抗体
zgc:171574 抗体
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