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抗Human GIPC1 抗体:
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Human Polyclonal GIPC1 Primary Antibody for IHC (p), IHC - ABIN250102
Wu, Haruta, Wei: GIPC1 interacts with MyoGEF and promotes MDA-MB-231 breast cancer cell invasion. in The Journal of biological chemistry 2010
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VEGF-A interacts with NRP-1 and GIPC1 to regulate alpha6/beta4-integrin, FAK, Src, PI3K/PDK1, LATS1 signaling to increase YAP1/Np63alpha accumulation.
Upregulated expression of GIPC1 is associated with glioma.
Drd3 palmitoylation acts as a molecular switch for Drd3-biased signaling via a GIPC1-dependent route, which is likely to affect the mode of action of antipsychotic drugs.
The composite biomarker, CAPG and GIPC1 in primary breast tumors, predicted disease outcomes and benefit from zoledronate and may facilitate patient selection for adjuvant bisphosphonate treatment.
GIPC status determines the loading of cellular cargo in the exosome in pancreatic cancer cells.
GIPC binds LPA(1) and promotes its trafficking from APPL-containing signaling endosomes to EEA1 early endosomes and thus attenuates LPA-mediated Akt signaling from APPL endosomes.
Our results do not show a predictive or prognostic function of GIPC1/Synectin expression for the outcome of radiotherapy in prostate cancer.
a novel non-Smad function for endoglin and GIPC in regulating endothelial cell function during angiogenesis
The placental lectins reduced the binding of IGF-I to IGF-1 receptor in a dose-dependent manner.
Knockdown of ADRM1 in amplified ovarian cell-line OAW42 results in downregulation of growth factor GIPC1 and upregulation of tumor-suppressor RECK RNA and protein
GIPC1 plays an essential role in oncogenic transformation, and its expression is necessary for the survival of human breast and colorectal cancer cells
interactions between TRP1-GIPC and GIPC-APPL-AKT provide a potential link between melanogenesis and PI3 kinase signaling
aim was to evaluate associations with albuminuria of six GLUT1 single nucleotide polymorphisms(SNPs), particularly XbaI and the previously associated Enhancer-2 (Enh2) SNP
Findings show the importance of GIPC in breast tumor progression.
GIPC1-MyoGEF complex formation plays an important role in regulating MDA-MB-231 breast cancer cell polarization and invasion.
Among several HBc-interacting partners selected, it interacted most strongly with the human protein GIPC1.
Data show that downregulation of myosin VI expression results in a significant reduction in PSA and VEGF secretion in LNCaP cells, and the intracellular targeting seems to involve myosin VI-interacting proteins, GIPC and LMTK2 and Dab2.
The PDZ domain of TIP-2/GIPC interacts with the C-terminus of the integrin alpha5 and alpha6 subunits.
expression of human GIPC1 mRNA in normal tissues, cancer cell lines, and primary tumors
GIPC can regulate beta1-adrenergic receptor-stimulated, Gi-mediated, ERK activation while having no effect on receptor internalization or Gs-mediated cAMP signaling
Silencing of gipc1 in tadpoles caused lymphatic defects due to an underdevelopment and impaired migration of Prox-1(+) lymphatic endothelial cells.
These data support a model where region specific mesoderm induction acts through kermit2 to regulate the temporally and spatially restricted changes in adhesive properties of the alpha5beta1 integrin through receptor endocytosis.
Results indicate that kermit 2/XGIPC is a novel component of the IGF pathway, potentially functioning through modulation of the IGF1 receptor.
Morpholino knockdown of synectin in zebrafish impaired formation of the thoracic duct, due to selective defects in lymphangiogenic but not angiogenic sprouting.
GIPC1 forms a domain-swapped dimer in an autoinhibited conformation that hinders binding of both PlexinD1 and myosin VI. PlexinD1 binding to GIPC1 releases the autoinhibition, promoting its interaction with myosin VI. GIPCs and myosin VI interact through two distinct interfaces and form an open-ended alternating array.
Down-regulation of endogenous GIPC1 is sufficient to inhibit the development of eye field cells from embryonic stem cells.
Higher ratios of PSD-95/GluN2B and GAIP-interacting protein C-terminus (GIPC)/GluN2B were associated with poorer learning index scores across all ages.
findings identify Gipc1 as a new interactor for Vangl2; show that a myosin VI-Gipc1 protein complex can regulate Vangl2 traffic in heterologous cells; results indicate a broad role for Gipc1 in the development of both stereociliary bundles and cell polarization
TGFbetaR3 interaction with GIPC1 is critical for regulating invasion and growth factor responsiveness in epicardial cells, and dysregulation of epicardial cell proliferation and invasion contributes to failed coronary vessel development in Tgfbr3(-/-) mice
Synectin is widely distributed in adult cells and tissues, and in the embryo apparent at day 4.5, peaks at day 12.5 and declines by day 18.5, and may be involved in mediation of outside-in signaling.
Synectin selectively regulates arterial branching morphogenesis.
Results define an important role for the Myo6-GIPC1 motor complex in presynaptic function and in BDNF-TrkB-mediated synaptic plasticity.
a prototypical GIPC/synectin-binding receptor, revealed that deletion of its PDZ-binding motif drastically reduced GIPC/synectin and myosin VI recruitment to endocytic vesicles
results confirm synectin involvement in FGF2-dependent signal transduction and provide insights into synectin-dependent gene expression in the endothelium
Plays a role in arteriolar development.
Endoglin promotes transforming growth factor beta-mediated Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC
synectin deficiency results in increased degradation of PDGF-BB protein in arterial endothelial cell and, consequently, reduced recruitment of mural cells to newly forming arteries
Fibroblast growth factor 2-induced Rac1 activation depends on the suppression of RhoG by a previously uncharacterized ternary S4-synectin-RhoGDI1 protein complex and activation via PKCalpha.
GIPC1 is a scaffolding protein that regulates cell surface receptor expression and trafficking (Lee et al., 2008
GAIP C-terminus-interacting protein
, GLUT1 C-terminal binding protein
, IGF-1 receptor interacting protein 1
, PDZ domain-containing protein GIPC1
, RGS-GAIP-interacting protein
, RGS19-interacting protein 1
, regulator of G-protein signalling 19 interacting protein 1
, tax interaction protein 2
, developmental regulator
, PDZ domain-containing protein
, regulator of G-protein signaling 19-interacting protein 1
, GIPC PDZ domain containing family, member 1
, GIPC PDZ domain containing family, member 3
, RGS-GAIP interacting protein GIPC
, Tax interacting protein, clone 2
, regulator of G-protein signaling 19 interacting protein 1
, semaF cytoplasmic domain associated protein
, semaF cytoplasmic domain-associated protein 1
, GLUT1 C-terminal-binding protein
, RGS-GAIP interacting protein C-terminus
, RGS-GAIP interacting protein, C-terminus
, rgs-gaip interacting protein gipc