DAB2 抗体
(Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2))
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
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71 results
DAB2
适用: 人, 小鼠, 大鼠, 猴
WB, ELISA, IHC, FACS, IF, ICC
宿主: 兔
Polyclonal
unconjugated
Latest Publications for our DAB2 抗体
: "Alpha-AP-2 directs myosin VI-dependent endocytosis of cystic fibrosis transmembrane conductance regulator chloride channels in the intestine." in: The Journal of biological chemistry, Vol. 285, Issue 22, pp. 17177-87, (2010) (PubMed).: "TGF-beta-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI." in: Nature cell biology, Vol. 12, Issue 3, pp. 286-93, (2010) (PubMed).
: "Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 44, pp. 18722-7, (2009) (PubMed).
: "Cutting edge: Dab2 is a FOXP3 target gene required for regulatory T cell function." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 7, pp. 4192-6, (2009) (PubMed).
: "Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions." in: Oncogene, Vol. 28, Issue 33, pp. 2999-3007, (2009) (PubMed).
: "Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor." in: The EMBO journal, Vol. 21, Issue 18, pp. 4915-26, (2002) (PubMed).
: "The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway." in: The EMBO journal, Vol. 20, Issue 11, pp. 2789-801, (2001) (PubMed).
: "Disabled-2 mediates c-Fos suppression and the cell growth regulatory activity of retinoic acid in embryonic carcinoma cells." in: The Journal of biological chemistry, Vol. 276, Issue 50, pp. 47303-10, (2001) (PubMed).
: "Cloning of a novel phosphoprotein regulated by colony-stimulating factor 1 shares a domain with the Drosophila disabled gene product." in: The Journal of biological chemistry, Vol. 270, Issue 23, pp. 14184-91, (1995) (PubMed).
Aliases for DAB2 抗体
DAB2, clathrin adaptor protein (DAB2) 抗体disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) (dab2) 抗体
Dab, mitogen-responsive phosphoprotein, homolog 2 (dab2) 抗体
DAB2, clathrin adaptor protein (Dab2) 抗体
disabled 2, mitogen-responsive phosphoprotein (Dab2) 抗体
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