The protein encoded by this gene contains 2 leucine zipper domains and a putative C-terminal nuclear targeting signal, but does not have any hydrophobic regions. This protein is expressed weakly in resting NK and T cells. The encoded protein modulates the activation of ARF genes by CYTH1. This protein interacts with CYTH1 and SNX27 proteins and may act to sequester CYTH1 protein in the cytoplasm.[provided by RefSeq, Aug 2008].
Tang, Cheng, Agnello, Wu, Hissong, Watford, Ahn, Galon, Moss, Vaughan, OShea, Gadina: "Cybr, a cytokine-inducible protein that binds cytohesin-1 and regulates its activity." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 5, pp. 2625-9, (2002) (PubMed).