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CYP7A1 产品

(Cytochrome P450, Family 7, Subfamily A, Polypeptide 1 (CYP7A1))
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis. [provided by RefSeq, Feb 2010].

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Featured CYP7A1 Categories

CYP7A1 抗体

High quality antibodies with extensive validation data.

CYP7A1 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

CYP7A1 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended CYP7A1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IF (cc), IF (p), IHC (p)
Validations
  • (7)
  • (2)
Cat. No. ABIN739725
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse
Application WB, IHC, IP, ICC
Validations
  • (2)
Cat. No. ABIN7433078
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, ELISA
Validations
  • (2)
Cat. No. ABIN7147604
Quantity 100 μg
Datasheet Datasheet

Recommended CYP7A1 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6966253
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6966254
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6955264
Quantity 96 tests
Datasheet Datasheet

Recommended CYP7A1 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN2565181
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7393070
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7393073
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our CYP7A1 Products

Chen, Wu: "Role of Baicalin and Liver X Receptor Alpha in the Formation of Cholesterol Gallstones in Mice." in: Gastroenterology research and practice, Vol. 2020, pp. 1343969, (2020) (PubMed).

Wang, Liao, Zhou, Bao, Ma, Zheng, Wang, Liu, Wang, Wang, Liu, Liu: "Parabacteroides distasonis Alleviates Obesity and Metabolic Dysfunctions via Production of Succinate and Secondary Bile Acids." in: Cell reports, Vol. 26, Issue 1, pp. 222-235.e5, (2020) (PubMed).

Zhang, Wang, Hao, Wang, Zhang, Muhammad, Qi, Li, Sun: "Nrf2 is crucial for the down-regulation of Cyp7a1 induced by arachidonic acid in Hepg2 cells." in: Environmental toxicology and pharmacology, Vol. 52, pp. 21-26, (2017) (PubMed).

Guo, Hassan, Zhang, Dong, Ding, Wang, Sun, Zhang, Jiang: "Pyrazinamide Induced Rat Cholestatic Liver Injury through Inhibition of FXR Regulatory Effect on Bile Acid Synthesis and Transport." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 152, Issue 2, pp. 417-28, (2016) (PubMed).

Kou, Han, Wang, Huang, He, Han, Zhou, Ye, Li: "Synergetic cholesterol-lowering effects of main alkaloids from Rhizoma Coptidis in HepG2 cells and hypercholesterolemia hamsters." in: Life sciences, Vol. 151, pp. 50-60, (2016) (PubMed).

Nukaya, Minami, Hoshikawa, Yokoi, Seino: "Preferential gene expression and epigenetic memory of induced pluripotent stem cells derived from mouse pancreas." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 20, Issue 5, pp. 367-81, (2015) (PubMed).

Wang, He, Lin, Li, Sun, Gu, Yu, Zhao: "In vitro effects of active components of Polygonum Multiflorum Radix on enzymes involved in the lipid metabolism." in: Journal of ethnopharmacology, Vol. 153, Issue 3, pp. 763-70, (2014) (PubMed).

Wang, Xiaoling, Pingting, Shuqiang, Yuaner: "Chronic unpredictable mild stress combined with a high-fat diets aggravates atherosclerosis in rats." in: Lipids in health and disease, Vol. 13, pp. 77, (2014) (PubMed).

Wu, He, Wang, Xue, Ning, Zou, Ye, Li, Wang, Pang: "The antihypercholesterolemic effect of jatrorrhizine isolated from Rhizoma Coptidis." in: Phytomedicine : international journal of phytotherapy and phytopharmacology, Vol. 21, Issue 11, pp. 1373-81, (2014) (PubMed).

Gabbi, Bertolotti, Anzivino, Macchioni, Del Puppo, Ricchi, Carubbi, Tagliafico, Romagnoli, Odoardi, Loria, Losi, Carulli: "Effects of bile duct ligation and cholic acid treatment on fatty liver in two rat models of non-alcoholic fatty liver disease." in: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, Vol. 44, Issue 12, pp. 1018-26, (2012) (PubMed).

Synonyms and alternative names related to CYP7A1

cytochrome P450 family 7 subfamily A member 1 (CYP7A1), cytochrome P450, family 7, subfamily a, polypeptide 1 (Cyp7a1), cytochrome P450, family 7, subfamily A, polypeptide 1 (CYP7A1), cytochrome P450 family 7 subfamily A member 1 (Cyp7a1), cholesterol 7-alpha-hydroxylase (Cyp7a1), cytochrome P450, family 7, subfamily A, polypeptide 1 (cyp7a1), CHAP, CP7A, CYP7, cyp7a1a, CYP7S1, CYPVII, zgc:63920

Protein level used designations for CYP7A1

  • cholesterol 7-alpha-hydroxylase
  • cholesterol 7-alpha-monooxygenase
  • cytochrome P450 7A1
  • cytochrome P450, subfamily VIIA polypeptide 1
  • CYPVII
  • cholesterol 7 alpha hydroxylase
  • cytochrome P450, 7a1
  • cholesterol 7 alpha-hydroxylase
  • cholesterol 7alpha-hydroxylase
  • cholesterol 7-alpha hydroxylase
  • cytochrome P450 (cholesterol hydroxylase 7 alpha)
  • Cholesterol 7-alpha-hydroxylase
  • Cytochrome P450 7A1
  • cytochrome P450, family 7, subfamily A, polypeptide 1a
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