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CYP46A1 产品

(Cytochrome P450, Family 46, Subfamily A, Polypeptide 1 (CYP46A1))

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This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. [provided by RefSeq, Jul 2008].

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Featured CYP46A1 Categories

CYP46A1 抗体

High quality antibodies with extensive validation data.

CYP46A1 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

CYP46A1 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended CYP46A1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IP
Validations
  • (3)
Cat. No. ABIN524256
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7190421
Quantity 100 μL
Datasheet Datasheet
Reactivity Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rat
Application WB
Validations
  • (3)
Cat. No. ABIN2773829
Quantity 100 μL
Datasheet Datasheet

Recommended CYP46A1 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6955263
Quantity 96 tests
Datasheet Datasheet

Recommended CYP46A1 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1351000
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3119551
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3120164
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our CYP46A1 Products

Ishikawa, Yoshitomi, Zorumski, Izumi: "24(S)-Hydroxycholesterol protects the ex vivo rat retina from injury by elevated hydrostatic pressure." in: Scientific reports, Vol. 6, pp. 33886, (2016) (PubMed).

Pikuleva: "Cytochrome P450s and cholesterol homeostasis." in: Pharmacology & therapeutics, Vol. 112, Issue 3, pp. 761-73, (2006) (PubMed).

Brown, Theisler, Silberman, Magnuson, Gottardi-Littell, Lee, Yager, Crowley, Sambamurti, Rahman, Reiss, Eckman, Wolozin: "Differential expression of cholesterol hydroxylases in Alzheimer's disease." in: The Journal of biological chemistry, Vol. 279, Issue 33, pp. 34674-81, (2004) (PubMed).

Mast, Norcross, Andersson, Shou, Nakayama, Bjorkhem, Pikuleva: "Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain." in: Biochemistry, Vol. 42, Issue 48, pp. 14284-92, (2003) (PubMed).

Synonyms and alternative names related to CYP46A1

cytochrome P450 family 46 subfamily A member 1 (CYP46A1), cytochrome P450 family 46 subfamily A member 1 L homeolog (cyp46a1.L), cytochrome P450, family 46, subfamily A, polypeptide 1, tandem duplicate 1 (cyp46a1.1), cytochrome P450, family 46 (cyp46a1), cytochrome P450 46A1 (PTRG_08343), cytochrome P450 46A1 (PTRG_09667), cytochrome P450, family 46, subfamily a, polypeptide 1 (Cyp46a1), cholesterol 24-hydroxylase (Sgly_1093), cytochrome P450, family 46, subfamily A, polypeptide 1 (CYP46A1), CP46, CYP46, Cyp46, CYP46A1, MGC147389, zgc:109896

Protein level used designations for CYP46A1

  • CH24H
  • cholesterol 24-hydroxylase
  • cytochrome P450 46A1
  • cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase)
  • cytochrome P450, family 46, subfamily A, polypeptide 1
  • cytochrome P450, family 46
  • cholestrol 24-hydroxylase
  • cytochrome P450, 46 (cholesterol 24-hydroxylase)
  • cytochrome P450, 46a1 (cholesterol 24-hydroxylase)
  • cholesterol-24S-hydroxylase
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