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Cullin 1 蛋白

(Cullin 1 (CUL1))
Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'\; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(Cyclin F) directs ubiquitination of CP110 (By similarity).

11 results :

custom-made CUL1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
产品编号 ABIN7565210
 
custom-made CUL1 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
产品编号 ABIN7553606
 
CUL1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Pubmed 1 reference
产品编号 ABIN1350756
 
CUL1 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant > 95% by SDS-PAGE SDS
产品编号 ABIN667243
 
CUL1 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant Greater than 90 % by SDS-PAGE gel analyses WB, ELISA
产品编号 ABIN7122515
 
CUL1 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant WB, SDS, ELISA
产品编号 ABIN7576435
 
CUL1 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant > 95 % WB, SDS, Imm, PC
产品编号 ABIN7418857
 
CUL1 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant > 95 % pure SDS
产品编号 ABIN2128764
 
custom-made CUL1 宿主: 小鼠 宿主: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). WB, SDS, ELISA
产品编号 ABIN3137494
 
custom-made CUL1 宿主: 人 宿主: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). WB, SDS, ELISA
产品编号 ABIN3092025
 
CUL1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
产品编号 ABIN2712629
 
  • 类型 Protein
    • Protein
  • 应用范围
    • SDS-PAGE (SDS)
    • Western Blotting (WB)
    • ELISA
    • Affinity Purification (AP)
    • Antibody Array (AA)
    • Antibody Production (AbP)
    • Immunogen (Imm)
    • Positive Control (PC)
    • Standard (STD)
  • 适用
    • Human
    • Mouse
  • 论文引用
  • 图像
  • Carrier free only
  • 抗体来源
    • Escherichia coli (E. coli)
    • HEK-293 Cells
    • Cell-free protein synthesis (CFPS)
    • Wheat germ
  • 抗原表位
    • AA 1-776
    • AA 1-250
    • AA 1-410
    • AA 477-776
  • 标记
    • His tag
    • Strep Tag
    • GST tag
    • His-IF2DI Tag
    • Myc-DYKDDDDK Tag
    • 非结合性
  • 蛋白类型
    • Recombinant
  • Format
    • Liquid
    • Lyophilized
  • Grade
    • custom-made
  • Supplier
    • antibodies-online
    • OriGene

Latest Publications for our Cullin 1 蛋白

Mallampalli, Glasser, Coon, Chen: "Calmodulin protects Aurora B on the midbody to regulate the fidelity of cytokinesis." in: Cell cycle (Georgetown, Tex.), Vol. 12, Issue 4, pp. 663-73, (2013) (PubMed).

Aliases for Cullin 1 蛋白

cullin 1 (CUL1) 蛋白
cullin-1 (LOC100282292) 蛋白
cullin 1 (cul1) 蛋白
cullin-1 (ATEG_00491) 蛋白
cullin-1 (EDI_072700) 蛋白
cullin-1 (EDI_264400) 蛋白
Cullin 1 (SJAG_02591) 蛋白
Cullin-1 (BDBG_03785) 蛋白
cullin 1 (Cul1) 蛋白
cullin 1a (cul1a) 蛋白
cullin 1 S homeolog (cul1.S) 蛋白
Cullin-1 (cul-1) 蛋白
cullin 1b (cul1b) 蛋白
ATCUL1 蛋白
AUXIN RESISTANT 6 蛋白
AXR6 蛋白
Cul-1 蛋白
Cul1 蛋白
cul1 蛋白
Cullin-1 蛋白
cullin-1 蛋白
cullin 1 蛋白
LOC100282292 蛋白
T10P11.26 蛋白
T10P11_26 蛋白
wu:fc13a10 蛋白
wu:fi43h07 蛋白
wu:fj43a08 蛋白
zgc:55483 蛋白
zgc:55747 蛋白
zgc:77500 蛋白
zgc:111899 蛋白
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