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Cullin 1 抗体

(Cullin 1 (CUL1))
Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'\; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(Cyclin F) directs ubiquitination of CP110 (By similarity).

74 results :

CUL1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
Pubmed 2 references
产品编号 ABIN3015864
 
CUL1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7180924
 
CUL1 适用: 人, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6261114
 
CUL1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7444775
 
CUL1 适用: 人 WB, IF, PLA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN521913
 
CUL1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6261106
 
CUL1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7184769
 
CUL1 适用: 人, 小鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3184129
 
CUL1 适用: 人 WB, IHC, ELISA, IP, IHC (p) 宿主: 小鼠 Monoclonal unconjugated
产品编号 ABIN337174
 
CUL1 适用: 人, 小鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN1533244
 
CUL1 适用: 人, 小鼠, 大鼠, 小鸡, Cow, 犬, Pig, 兔 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7297374
 
CUL1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7148748
 
CUL1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7148747
 
CUL1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN791065
 
CUL1 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7260209
 
CUL1 适用: 人, 小鼠, 大鼠, 小鸡, 斑马鱼, Cow, 犬, 非洲爪蟾, Pig, 兔, Bat, 豚鼠, 马, 猴, Hamster WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN202908
 
CUL1 适用: 人, 小鼠, 大鼠, 小鸡, 斑马鱼, 犬, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN926003
 
CUL1 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3042671
 
KD Validated CUL1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IP, ICC, FACS 宿主: 兔 Monoclonal unconjugated Recombinant Antibody
产品编号 ABIN7606988
 
CUL1 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3030576
 
  • 类型 Primary
    • Primary
  • 应用范围
    • Western Blotting (WB)
    • ELISA
    • Immunohistochemistry (IHC)
    • Immunofluorescence (IF)
    • Immunofluorescence (Cultured Cells) (IF (cc))
    • Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    • Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    • Immunoprecipitation (IP)
    • Immunocytochemistry (ICC)
    • Immunohistochemistry (Frozen Sections) (IHC (fro))
    • Flow Cytometry (FACS)
    • Proximity Ligation Assay (PLA)
    • Enzyme Immunoassay (EIA)
    • Immunochromatography (IC)
    • Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))
  • 适用
    • Human
    • Mouse
    • Rat
    • Chicken
    • Zebrafish (Danio rerio)
    • Cow
    • Dog
    • Xenopus laevis
    • Pig
    • Rabbit
    • Bat
    • Guinea Pig
    • Horse
    • Monkey
    • Hamster
    • Sheep
  • 论文引用
  • 图像
  • Preservative free only
  • Carrier free only
  • 抗体来源
    • Rabbit
    • Mouse
  • 克隆形成能力
    • Polyclonal
    • Monoclonal
  • 克隆
    • ADIA-3
    • R05-3D2
  • 抗原表位
    • AA 701-776
    • C-Term
    • AA 680-708
    • AA 500-776
    • N-Term
    • AA 1-250
    • AA 1-776
    • AA 250-300
    • AA 34-52
    • AA 726-776
    • AA 457-770
    • AA 679-708
    • AA 727-776
    • AA 742-752
    • Tyr761
  • 标记
    • 非结合性
    • Biotin
    • Alexa Fluor 488
    • Alexa Fluor 555
    • Alexa Fluor 594
    • Alexa Fluor 647
    • Alexa Fluor 680
    • Alexa Fluor 750
    • FITC
    • HRP
    • APC
    • AbBy Fluor® 350
    • AbBy Fluor® 488
    • AbBy Fluor® 555
    • AbBy Fluor® 594
    • AbBy Fluor® 647
    • AbBy Fluor® 680
    • AbBy Fluor® 750
    • Cy3
    • Cy5
    • Cy5.5
    • Cy7
    • PE
  • 抗体亚型
    • IgG
    • Ig Fraction
    • IgG1 kappa
  • 蛋白类型
    • Recombinant Antibody
  • Format
    • Liquid
    • Lyophilized
  • Grade
    • KD Validated
  • Supplier
    • antibodies-online
    • Signalway
    • Boster Bio
    • Acris
    • Assay Biotechnology Company, Inc.
    • Aviva Systems Biology
    • Biomatik
    • Cohesion Biosciences
    • NSJ Bioreagents
    • ProSci
    • USBio

Latest Publications for our Cullin 1 抗体

Mao, Xiong, Huang, Zheng, Yao: "Expression of CUL1 correlates with tumour-grade and recurrence in urothelial carcinoma." in: ANZ journal of surgery, Vol. 87, Issue 7-8, pp. 624-629, (2018) (PubMed).

Benesova, Kinterova, Kanka, Toralova: "Potential Involvement of SCF-Complex in Zygotic Genome Activation During Early Bovine Embryo Development." in: Methods in molecular biology (Clifton, N.J.), Vol. 1605, pp. 245-257, (2018) (PubMed).

Chen, Xu, Yang, Zhang, Wu, Chen, Li, Wang, Li, Li, Dai: "Upregulation of miR-223 in the rat liver inhibits proliferation of hepatocytes under simulated microgravity." in: Experimental & molecular medicine, Vol. 49, Issue 6, pp. e348, (2018) (PubMed).

Lutz, Pace, Arnold: "Rotavirus NSP1 Associates with Components of the Cullin RING Ligase Family of E3 Ubiquitin Ligases." in: Journal of virology, Vol. 90, Issue 13, pp. 6036-48, (2016) (PubMed).

Liao, Jiang, He, Ni, Tu, Zhang, Wang, Lou, Quan, Wang: "NEDD8-mediated neddylation is required for human endometrial stromal proliferation and decidualization." in: Human reproduction (Oxford, England), Vol. 30, Issue 7, pp. 1665-76, (2016) (PubMed).

Jiang, He, Xu, Liu, Qu, Tong: "Cullin-1 promotes cell proliferation via cell cycle regulation and is a novel in prostate cancer." in: International journal of clinical and experimental pathology, Vol. 8, Issue 2, pp. 1575-83, (2015) (PubMed).

Enchev, Scott, da Fonseca, Schreiber, Monda, Schulman, Peter, Morris: "Structural basis for a reciprocal regulation between SCF and CSN." in: Cell reports, Vol. 2, Issue 3, pp. 616-27, (2012) (PubMed).

Duda, Borg, Scott, Hunt, Hammel, Schulman: "Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation." in: Cell, Vol. 134, Issue 6, pp. 995-1006, (2008) (PubMed).

Hatakeyama, Kitagawa, Nakayama, Shirane, Matsumoto, Hattori, Higashi, Nakano, Okumura, Onoé, Good, Nakayama: "Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 7, pp. 3859-63, (1999) (PubMed).

Ohta, Michel, Schottelius, Xiong: "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity." in: Molecular cell, Vol. 3, Issue 4, pp. 535-41, (1999) (PubMed).

Aliases for Cullin 1 抗体

cullin 1 (CUL1) 抗体
cullin-1 (LOC100282292) 抗体
cullin 1 (cul1) 抗体
cullin-1 (ATEG_00491) 抗体
cullin-1 (EDI_072700) 抗体
cullin-1 (EDI_264400) 抗体
Cullin 1 (SJAG_02591) 抗体
Cullin-1 (BDBG_03785) 抗体
cullin 1 (Cul1) 抗体
cullin 1a (cul1a) 抗体
cullin 1 S homeolog (cul1.S) 抗体
Cullin-1 (cul-1) 抗体
cullin 1b (cul1b) 抗体
ATCUL1 抗体
AUXIN RESISTANT 6 抗体
AXR6 抗体
Cul-1 抗体
Cul1 抗体
cul1 抗体
Cullin-1 抗体
cullin-1 抗体
cullin 1 抗体
LOC100282292 抗体
T10P11.26 抗体
T10P11_26 抗体
wu:fc13a10 抗体
wu:fi43h07 抗体
wu:fj43a08 抗体
zgc:55483 抗体
zgc:55747 抗体
zgc:77500 抗体
zgc:111899 抗体
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