The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for cancer. [provided by RefSeq, Jul 2008].
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Asplund, Gry Björklund, Sundquist, Strömberg, Edlund, Ostman, Nilsson, Pontén, Lundeberg: "Expression profiling of microdissected cell populations selected from basal cells in normal epidermis and basal cell carcinoma." in: The British journal of dermatology, Vol. 158, Issue 3, pp. 527-38, (2008) (PubMed).
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Aliases for CSTA 抗体
cystatin A (CSTA) 抗体 cystatin A1 (Csta1) 抗体 cystatin A (Csta) 抗体 cystatin A (CYSA) 抗体 cystatin-A (LOC100725920) 抗体 AREI 抗体 ATCYSA 抗体 CST 抗体 CSTA 抗体 cystatin A 抗体 FL3-27 抗体 STF1 抗体 STFA 抗体 T20B5.8 抗体 T20B5_8 抗体