This gene encodes a protein that functions in multiple regulatory pathways. The encoded protein complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activation and cytoskeletal organization. The protein is also found associated with the plasma membrane where it functions as a chloride current regulator. Pseudogenes of this gene are found on chromosomes 1, 4 and 6. [provided by RefSeq, Feb 2009].
Pu, Krapivinsky, Krapivinsky, Clapham: "pICln inhibits snRNP biogenesis by binding core spliceosomal proteins." in: Molecular and cellular biology, Vol. 19, Issue 6, pp. 4113-20, (1999) (PubMed).
Krapivinsky, Pu, Wickman, Krapivinsky, Clapham: "pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology." in: The Journal of biological chemistry, Vol. 273, Issue 18, pp. 10811-4, (1998) (PubMed).
Sanchez-Olea, Emma, Coghlan, Strange: "Characterization of pICln phosphorylation state and a pICln-associated protein kinase." in: Biochimica et biophysica acta, Vol. 1381, Issue 1, pp. 49-60, (1998) (PubMed).