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CLCN3 产品

(Chloride Channel 3 (CLCN3))

Categories

This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011].

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Featured CLCN3 Categories

CLCN3 抗体

High quality antibodies with extensive validation data.

CLCN3 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended CLCN3 抗体

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Datasheet

Application WB, IHC
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  • (1)
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Cat. No. ABIN2776327
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC, ELISA
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Cat. No. ABIN6260874
Quantity 100 μL
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Cat. No. ABIN1027722
Quantity 100 μg
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Recommended CLCN3 蛋白

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Source Wheat germ
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Quantity 10 μg
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Source Escherichia coli (E. coli)
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Cat. No. ABIN3134383
Quantity 1 mg
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Reactivity Human
Source Escherichia coli (E. coli)
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Cat. No. ABIN3077940
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Latest Publications for our CLCN3 Products

Eckenstaler, Lessmann, Brigadski: "CAPS1 effects on intragranular pH and regulation of BDNF release from secretory granules in hippocampal neurons." in: Journal of cell science, Vol. 129, Issue 7, pp. 1378-90, (2016) (PubMed).

Gaurav, Bewtra, Agrawal: "Novel CLC3 transcript variants in blood eosinophils and increased CLC3 expression in nasal lavage and blood eosinophils of asthmatics." in: Immunity, inflammation and disease, Vol. 2, Issue 4, pp. 205-13, (2015) (PubMed).

Larrouture, Nelson, Robinson, Liu, Tourkova, Schlesinger, Blair: "Chloride-hydrogen antiporters ClC-3 and ClC-5 drive osteoblast mineralization and regulate fine-structure bone patterning in vitro." in: Physiological reports, Vol. 3, Issue 11, (2015) (PubMed).

Cuddapah, Turner, Sontheimer: "Calcium entry via TRPC1 channels activates chloride currents in human glioma cells." in: Cell calcium, Vol. 53, Issue 3, pp. 187-94, (2013) (PubMed).

Jensen, Nosjean, Dziegiel, Boutin, Sørensen, Karsdal, Henriksen: "A quantitative assay for lysosomal acidification rates in human osteoclasts." in: Assay and drug development technologies, Vol. 9, Issue 2, pp. 157-64, (2011) (PubMed).

McMains, Krishnan, Prasad, Gleason: "Expression and localization of CLC chloride transport proteins in the avian retina." in: PLoS ONE, Vol. 6, Issue 3, pp. e17647, (2011) (PubMed).

Synonyms and alternative names related to CLCN3

chloride voltage-gated channel 3 (CLCN3), chloride voltage-gated channel 3 (Clcn3), chloride channel, voltage-sensitive 3 (Clcn3), chloride channel 3 (clcn3), chloride channel protein 3 (PTRG_03131), chloride channel protein 3 (BDBG_05668), chloride channel protein 3 (MCYG_04420), chloride channel, voltage-sensitive 3 (clcn3), chloride channel, voltage-sensitive 3 S homeolog (clcn3.S), ClC-3, clc-3, CLC3, Clc3, clc3, CLCN3, fb78c02, wu:fb78c02

Protein level used designations for CLCN3

  • H(+)/Cl(-) exchange transporter 3
  • chloride channel 3
  • chloride channel protein 3
  • chloride transporter ClC-3
  • protein kinase C-regulated chloride channel
  • clC-3
  • chloride channel Clc-3
  • Chloride channel protein 3
  • H(+)/Cl(-) exchange transporter 3-like
  • putative chloride channel ClC-3
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