CIITA 抗体
(Class II, Major Histocompatibility Complex, Transactivator (CIITA))
This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the 'master control factor' for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. [provided by RefSeq, Jul 2008].
| Catalog no. | 产品 | 适用 | 宿主 / 克隆类型 | 应用 | 价格和交货时间 |
|---|---|---|---|---|---|
| CIITA 抗体 (Alexa Fluor 594) | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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| CIITA 抗体 (Alexa Fluor 488) | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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| CIITA 抗体 (Center) | 人, 小鼠, 大鼠, Cow | 兔 Polyclonal |
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| CIITA 抗体 (Center) | 人, 小鼠 | 兔 Polyclonal |
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| CIITA 抗体 | 人, 大鼠 | 兔 Polyclonal |
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| CIITA 抗体 (AA 34-1038) | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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| CIITA 抗体 (Biotin) | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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Primary Antibody
- WB (Western Blotting: 所列应用)
- 适用
- 人, 小鼠, 大鼠, Cow
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗原表位
- Center
Primary Antibody
- WB (Western Blotting: 所列应用)
- 适用
- 人, 小鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗原表位
- Center
Primary Antibody
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- FACS (Flow Cytometry: 所列应用)
- 适用
- 人, 小鼠, 大鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- AA 34-1038
Latest Publications for our CIITA 抗体
: "A super enhancer controls expression and chromatin architecture within the MHC class II locus." in: The Journal of experimental medicine, Vol. 217, Issue 2, (2020) (PubMed).
: "Autoregulatory loop between TGF-β1/miR-411-5p/SPRY4 and MAPK pathway in rhabdomyosarcoma modulates proliferation and differentiation." in: Cell death & disease, Vol. 6, pp. e1859, (2016) (PubMed).
: "Genome-wide CIITA-binding profile identifies sequence preferences that dictate function versus recruitment." in: Nucleic acids research, Vol. 43, Issue 6, pp. 3128-42, (2015) (PubMed).
: "The 19S proteasome positively regulates histone methylation at cytokine inducible genes." in: Biochimica et biophysica acta, Vol. 1789, Issue 11-12, pp. 691-701, (2009) (PubMed).
: "Autoregulatory loop between TGF-β1/miR-411-5p/SPRY4 and MAPK pathway in rhabdomyosarcoma modulates proliferation and differentiation." in: Cell death & disease, Vol. 6, pp. e1859, (2016) (PubMed).
: "Genome-wide CIITA-binding profile identifies sequence preferences that dictate function versus recruitment." in: Nucleic acids research, Vol. 43, Issue 6, pp. 3128-42, (2015) (PubMed).
: "The 19S proteasome positively regulates histone methylation at cytokine inducible genes." in: Biochimica et biophysica acta, Vol. 1789, Issue 11-12, pp. 691-701, (2009) (PubMed).
Aliases for CIITA 抗体
class II, major histocompatibility complex, transactivator (CIITA) 抗体class II major histocompatibility complex transactivator (CIITA) 抗体
MHC class II transactivator (LOC710761) 抗体
class II, major histocompatibility complex, transactivator (ciita) 抗体
MHC class II transactivator (LOC100443575) 抗体
class II transactivator (Ciita) 抗体
MHC class II transactivator (LOC100736732) 抗体
class II, major histocompatibility complex, transactivator (Ciita) 抗体
C2ta 抗体
C2TA 抗体
CIITA 抗体
CIITAIV 抗体
EG669998 抗体
Gm9475 抗体
MHC2TA 抗体
Mhc2ta 抗体
NLRA 抗体
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