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Human Polyclonal LOXL2 Primary Antibody for ICC, IF - ABIN442901
Wong, Zhang, Gilkes, Chen, Wei, Chaturvedi, Hubbi, Semenza: Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis. in Journal of molecular medicine (Berlin, Germany) 2012
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Human Monoclonal LOXL2 Primary Antibody for ELISA, WB - ABIN561690
Fujimoto, Tajima: Reciprocal regulation of LOX and LOXL2 expression during cell adhesion and terminal differentiation in epidermal keratinocytes. in Journal of dermatological science 2009
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Human Polyclonal LOXL2 Primary Antibody for ELISA, WB - ABIN561689
Ghiggeri, Gigante, Di Donato et al.: Constitutional Nephrin Deficiency in Conditionally Immortalized Human Podocytes Induced Epithelial-Mesenchymal Transition, Supported by β-Catenin/NF-kappa B Activation: A Consequence of Cell Junction ... in International journal of nephrology 2014
Dmloxl-1 and Dmloxl-2 are differentially expressed; active DmLOXL-1 influences gene expression and development
HIF-1alpha (显示 HIF1A 抗体) plays an important role in the development of HCC (显示 FAM126A 抗体) by promoting HCC (显示 FAM126A 抗体) metastasis, EMT (显示 ITK 抗体) and VM through up-regulating LOXL2.
Participants were evaluated as part of a clinical trial evaluating the safety and efficacy of simtuzumab a humanized monoclonal antibody that inhibits lysyl oxidase-like 2 (LOXL2), an enzyme that contributes to liver fibrosis by catalyzing collagen cross-linkage
expression of LOXL2 endowed dormant tumor cells with cancer stem cell-like phenotype driving their transition to metastatic outgrowth and this stem-like phenotype is dependent on epithelial to mesenchymal transition (EMT (显示 ITK 抗体)) that can be driven by the tumor microenvironment.
Simtuzumab is a humanized IgG4 monoclonal antibody that inhibits enzymatic activity of LOXL2... inhibition of LOXL2 expression reduced numbers of activated fibroblasts, decreased ECM (显示 MMRN1 抗体) deposition, inhibited angiogenesis, and prevented tumor cell invasion and metastases
higher LOXL2 expression is associated with the invasiveness of pancreatic cancer cells and the low survival rate of pancreatic cancer patients
LOXL2 c.C133T is a pathogenic mutation that is responsible for a fraction of familial intracranial aneurysms.
data demonstrate that proteolytic processing is an important event that allows LOXL2-mediated crosslinking of basement membrane collagen IV (显示 COL4 抗体).
new LOXL2 splice variant contributes to tumor progression by novel molecular mechanisms different from LOXL2WT
LOXL2 is a potential therapeutic target against tumor progression.
Insulin (显示 INS 抗体) resistance promotes lysyl oxidase like 2 induction and fibrosis accumulation in non-alcoholic fatty liver disease.
Findings indicate a pathophysiologic role and function for lysyl oxidase (显示 LOX 抗体)-like protein LOXL2 (显示 LOXL3 抗体) in breast cancer metastasis.
Insulin (显示 INS 抗体) resistance promotes lysyl oxidase like 2 (显示 LOXL3 抗体) induction and fibrosis accumulation in non-alcoholic fatty liver disease.
glomerular extracellular matrix. Altogether, we demonstrate that LOXL2 (显示 LOXL3 抗体) is a novel component of the molecular machinery that forms cross-linked collagen IV (显示 COL4 抗体) networks, which are essential for glomerular basement membrane stability and molecular ultrafiltration function.
LOX (显示 LOX 抗体) and LOXL2 (显示 LOXL3 抗体) may play an important role in the pathogenesis of AMD (显示 AMD1 抗体). Targeting LOXL2 (显示 LOXL3 抗体) could have a broader efficacy than targeting LOX (显示 LOX 抗体), by reducing angiogenesis and inflammation, as well as fibrosis.
Loss and gain of function analyses combined with in vivo studies in syngeneic breast cancer models demonstrate the participation of LOXL2 (显示 LOXL3 抗体) and E47 (显示 TCF3 抗体) in tumor growth and their requirement for lung metastasis.
Findings reveal new insight into the mechanisms of fibroblast activation, a novel function of LOXL2 (显示 LOXL3 抗体), and further highlight the importance of generating LOXL2 (显示 LOXL3 抗体)-targeted therapies for the prevention of tumor progression and metastasis.
The Snail1 (显示 SNAI1 抗体) transcription factor represses mouse pericentromeric transcription, acting through the H3K4 deaminase LOXL2 (显示 LOXL3 抗体).
The enzymatic activity of lysyl oxidas-like-2 (LOXL2 (显示 LOXL3 抗体)) is not required for LOXL2 (显示 LOXL3 抗体)-induced inhibition of keratinocyte differentiation.
This study provides the first evidence for the role of LOXL2 (显示 LOXL3 抗体) in regulating angiogenesis through collagen IV (显示 COL4 抗体) scaffolding.
LOXL2 (显示 LOXL3 抗体) promotes chondrocyte differentiation by mechanisms that are likely to include roles as both a regulator and an effector of chondrocyte differentiation
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.
, lysyl oxidase-like 2
, Lysyl oxidase-like protein 2
, lysyl oxidase homolog 2
, lysyl oxidase homolog 2-like
, lysyl oxidase related 2
, lysyl oxidase-like protein 2
, lysyl oxidase-related protein 2
, lysyl oxidase-related protein WS9-14
, Lysyl oxidase homolog 2