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抗Mouse (Murine) BCL6 抗体:
抗Human BCL6 抗体:
抗Rat (Rattus) BCL6 抗体:
Human Monoclonal BCL6 Primary Antibody for IHC, WB - ABIN2668887
García, García, Maestre, Lucas, Sánchez-Verde, Romero-Chala, Piris, Roncador: Genetic immunization: a new monoclonal antibody for the detection of BCL-6 protein in paraffin sections. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2005
Show all 2 Pubmed References
Human Polyclonal BCL6 Primary Antibody for IF (p), IHC (p) - ABIN749843
Szabó, Gáspár, Dajnoki, Papp, Fábos, Szegedi, Zeher: Expansion of circulating follicular T helper cells associates with disease severity in childhood atopic dermatitis. in Immunology letters 2017
Human Polyclonal BCL6 Primary Antibody for ELISA, ICC - ABIN6260236
Huang, Zhang, Hou, Wang, Liu, Zhang, Chen, Zhu: LncRNA AK023391 promotes tumorigenesis and invasion of gastric cancer through activation of the PI3K/Akt signaling pathway. in Journal of experimental & clinical cancer research : CR 2018
Human Polyclonal BCL6 Primary Antibody for WB - ABIN4283623
Margalit, Amram, Amariglio, Simon, Shaklai, Granot, Minsky, Shimoni, Harmelin, Givol, Shohat, Oren, Rechavi: BCL6 is regulated by p53 through a response element frequently disrupted in B-cell non-Hodgkin lymphoma. in Blood 2006
BCL6 forms a complex with BCL6 corepressor (BCoR (显示 BCOR 抗体)) on the promoters of selected Notch (显示 NOTCH1 抗体) target genes such as enhancer of split related 1.
Bcl-6, expressed in abundance in Tfr (显示 TFRC 抗体) cells, inhibits CD25 (显示 IL2RA 抗体) expression and IL-21 (显示 IL21 抗体)-mediated inhibition of CD25 (显示 IL2RA 抗体) is Bcl-6 dependent.
Together these results identify BCL6 as a potential driver of ETV6 (显示 ETV6 抗体)-RUNX1 (显示 RUNX1 抗体)-mediated leukemogenesis, which could involve loss of BTG1 (显示 BTG1 抗体)-dependent suppression of ETV6 (显示 ETV6 抗体)-RUNX1 (显示 RUNX1 抗体) function.
this study shows that IL4 (显示 IL4 抗体) and IL21 (显示 IL21 抗体) cooperate to induce the high Bcl6 protein level required for germinal center formation
Although BCL6 controls follicular helper T cells activity in humans and mice, the role of miR (显示 MLXIP 抗体)-31 is restricted to human follicular helper T cell differentiation, reflecting a species specificity of the miR (显示 MLXIP 抗体)-31 action.
These findings indicate a role of the interaction between TH2-promoting factors and Bcl6 in promoting appropriate IL-4 (显示 IL4 抗体) production in mTH2 (显示 NUDT15 抗体) cells and suggest that chronic allergic diseases involve the TH2-promoting factor-mediated functional breakdown of Bcl6, resulting in allergy exacerbation.
Bioinformatics analysis and the dual-luciferase reporter assay demonstrated that miR (显示 MLXIP 抗体)-10b could target the 3'-untranslated regions of B cell lymphoma 6 (Bcl6) which is an important regulator of osteoblast differentiation.
Def6 (显示 DEF6 抗体) limits proliferation of T follicular helper cells in mice via alteration of mTORC1 signaling and inhibition of Bcl6 expression.
The balance between CD4 (显示 CD4 抗体)(+) cytotoxic T cell and follicular helper T(Tfh) differentiation heavily depends on the class of infecting virus and is jointly regulated by the Tfh-related transcription factors Bcl6 and Tcf7 (显示 TCF7 抗体) (encoding TCF-1 (显示 HNF1A 抗体)) and by the expression of the inhibitory receptors PD-1 (显示 PDCD1 抗体) and LAG3 (显示 LAG3 抗体).
Study provides evidence for an essential role of Bcl6 in the complex regulation of gene transcription during early adipogenesis. The action of Bcl6 is at least partially mediated by the direct transcriptional activation of STAT1 (显示 STAT1 抗体).
These data describe a novel regulatory mechanism through which STAT3 (显示 STAT3 抗体) and the Ikaros (显示 IKZF1 抗体) zinc finger transcription factors Aiolos (显示 IKZF3 抗体) and Ikaros (显示 IKZF1 抗体) cooperate to regulate Bcl-6 expression.
our exploratory study suggests that EOMES, BCL6 and GZMB gene expression are aberrant within the PB T cell transcriptome of HT patients. The association of this transcription signature with the heterogeneity of HT and disease control is suggested.
Cryptic t(3;8)(q27;q24) and/or MYC (显示 MYC 抗体)-BCL6 linkage associated with MYC (显示 MYC 抗体) expression by immunohistochemistry is frequent in multiple-hit B-cell lymphomas
BCL6 overexpression in SHR reduced blood pressure, NLRP3 expression and inflammation in the renal cortex of SHR
Aberrant CD10 (显示 MME 抗体) and BCL6 expression defines a subset of MCLs with higher mean Ki-67 (显示 MKI67 抗体) index and higher prevalence of MUM1 (显示 IRF4 抗体) expression
Double-hit lymphoma (DHL) is an aggressive form of DLBCL with an unmet treatment need, in which MYC (显示 MYC 抗体) rearrangement is present with either BCL2 (显示 BCL2 抗体) or BCL6 rearrangement
BCL6 is a growth promoting factor in glioblastoma and glioma.
IFN gamma induced (显示 SAMHD1 抗体) upregulation of BCL6 was dependent on the classical STAT1 (显示 STAT1 抗体) signaling pathway, and affected both major BCL6 variants. Interestingly, although IFN alpha induced stronger STAT1 (显示 STAT1 抗体) phosphorylation than IFN gamma (显示 IFNG 抗体), it only slightly upregulated BCL6 in multiple myeloma lines.
Findings demonstrate that BCL6 expression is downregulated by miR (显示 MLXIP 抗体)-519d which targets its 3 '-UTR (显示 UTS2R 抗体). Also, BCL6 mediates the repression of miR (显示 MLXIP 抗体)-519d on cell proliferation and invasive capability of gastric cancer cells.
In Pakistani population, the frequency of GCB (显示 GBA 抗体) type DLBCL [diffuse large B cell lymphoma ]expressing CD10 (显示 MME 抗体) and BCL6 is 37.5%, and non- GCB (显示 GBA 抗体) type DLBCL [diffuse large B cell lymphoma ] expressing MUM1 (显示 IRF4 抗体) is 62.5%.
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
B-cell CLL/lymphoma 6
, B-cell CLL/lymphoma 6 (zinc finger protein 51)
, B-cell lymphoma 6 protein
, zinc finger protein 51
, B-cell leukemia/lymphoma 5
, B-cell leukemia/lymphoma 6
, B-cell lymphoma 6 protein homolog
, B-cell lymphoma 5 protein
, B-cell lymphoma 6 protein transcript
, cys-his2 zinc finger transcription factor
, lymphoma-associated zinc finger gene on chromosome 3
, protein LAZ-3
, zinc finger and BTB domain-containing protein 27
, zinc finger transcription factor BCL6S